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Reagent for endotoxin-specific assay

  • US 5,550,030 A
  • Filed: 09/14/1993
  • Issued: 08/27/1996
  • Est. Priority Date: 09/14/1992
  • Status: Expired due to Term
First Claim
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1. A method for conducting an endotoxin-specific assay comprising applying a sample solution to a reagent for endotoxin-specific assay which comprises an insoluble carrier selected from the group consisting of polyamide and cellulose which has immobilized thereon one or more moieties, wherein at least one of said immobilized moieties is an endotoxin-sensitive factor that can be activated by endotoxin and that is derived from a limulus amebocyte lysate and wherein none of said immobilized moieties shows reactivity with a (1→

  • 3)-β



    -glucan, allowing endotoxin in the sample to react with at least the endotoxin-sensitive factor on said reagent, allowing said reagent to react with either a substrate that reacts with the immobilized endotoxin-sensitive factor after the immobilized endotoxin-sensitive factor has been activated by endotoxin or a substrate for limulus amebocyte lysate clotting enzyme, and determining a change of either of said substrate.

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