Centrifuge with pivot-out, easy-load processing chamber

• US 5,551,942 A
• Filed: 12/22/1993
• Issued: 09/03/1996
• Est. Priority Date: 12/22/1993
• Status: Expired due to Fees

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Brown, Richard I., Williamson, Warren P., Di Perna, Paul M.
• Primary Examiner(s): Scherbel, David
• Assistant Examiner(s): TILL, TERRENCE R
• Application Number:
  US08/176,425
• Time in Patent Office: 986 Days
• Field of Search: 494/16-18, 494/20, 494/21, 494/45
• US Class Current: 494/45
• CPC Class Codes: B04B 2005/045 having annular separation channels
• CPC Class Codes: B04B 5/0442 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: F02B 2075/025 two

Abstract

A centrifuge comprising a yoke element that rotates about a rotational axis and a processing chamber having an axis. The processing chamber includes a bowl element, a spool element, and a mechanism for joining the spool and bowl elements for relative movement between a mutually cooperating position for centrifugal processing and a mutually separated position for loading. A hinge attaches the processing chamber to the yoke element for pivotal movement between an operating position and an access position. In the operating position, the spool and bowl elements are in their mutually cooperating position and oriented for rotation with the yoke element about the rotational axis. In the access position, the processing chamber axis lies outside the axis of rotation and the spool and bowl elements are oriented for movement from their mutually cooperating position into their mutually separated position.

Claims

1. A centrifuge comprising

a yoke element including a base, a pair of arms extending from the base defining a space between the arms, a cross member, a hinge coupling the cross member to one of the arms for pivoting the cross member about the hinge between an operating position, in which the cross member extends across the space between the arms, and an access position, in which the cross member is cantilevered from the hinge outside the space between the arms,

a drive mechanism coupled to the base of the yoke element to rotate the yoke element about a rotational axis,

a processing chamber carried by the cross member for rotation about an axis and for pivoting with the cross member about the hinge between the operating position and the access position, the processing chamber including a bowl element having a wall defining an interior area, a spool element having an exterior surface, and a mechanism joining the spool and bowl elements for movement between a mutually cooperating position, in which the spool element is enclosed within the interior area of the bowl element to define the processing chamber between the bowl element wall and the exterior spool surface, and a mutually separated position, in which the spool element is at least partially out of the interior area of the bowl element to expose the exterior spool surface for access, and

the cross member, when in the operating position, orienting the spool and bowl elements in the space between the arms with the processing chamber axis oriented generally coaxial with the rotational axis for rotation with the yoke element about the rotational axis, and the cross member, when in the access position, orienting the spool and bowl elements outside the space between the arms and outside the rotational axis for movement from the mutually cooperating position into the mutually separated position.

2. A centrifuge according to claim 1

wherein the spool element includes means exposed when the spool and bowl elements are in the mutually separated position for receiving a processing element upon the spool exterior surface and for retaining the processing element within the processing chamber when the spool and bowl elements are moved to the mutually cooperating position.

3. A centrifuge according to claim 1

and further including a processing element that is located within the processing chamber when the spool and bowl elements are in the mutually cooperating position and that is removable therefrom when the spool and bowl are in the mutually separated position.

4. A centrifuge according to claim 3

and further including means for releasably holding tubing that conveys fluid into the processing element during centrifugal processing.

5. A centrifuge according to claim 1

and further including means for rotating the processing chamber about the processing chamber axis relative to the yoke assembly.

6. A centrifuge according to claim 1

and further including means operative when the cross member is in the operating position for rotating the processing chamber about the axis relative to the yoke assembly at a rate that is generally twice the rate at which the yoke assembly rotates.

7. A centrifuge comprising

a yoke element including a base, a pair of arms extending from the base defining a space between the arms, a cross member, a hinge coupling the cross member to one of the arms for pivoting the cross member about the hinge between an operating position, in which the cross member extends across the space between the arms, and an access position, in which the cross member is cantilevered from the hinge outside the space between the arms,

means coupled to the base of the yoke element for rotating the yoke element about a rotational axis,

a processing chamber carried by the cross member for rotation about a second axis and for pivoting with the cross member about the hinge between the operating position and the access position, the processing chamber including a bowl element having a wall defining an interior area, a spool element having an exterior surface, and means for joining the spool and bowl elements for movement between a mutually cooperating position, in which the spool element is enclosed within the interior area of the bowl element to define the processing chamber between the bowl element wall and the exterior spool surface, and a mutually separated position, in which the spool element is at least partially out of the interior area of the bowl element to expose the exterior spool surface for access,

the cross member, when in the operating position, orienting the spool and bowl elements in the space between the arms with the second axis oriented generally coaxial with the rotational axis for rotation with the yoke element, and the cross member, when in the access position, orienting the spool and bowl elements outside the space between the arms and outside the rotational axis for movement from the mutually cooperating position into the mutually separated position for access by the user,

an umbilicus in fluid communication with the processing chamber, the umbilicus having an upper region, a middle region, and a lower region,

a stationary first holder located above the yoke element that releasably receives the upper umbilicus region in alignment with the rotational axis,

a rotating second holder on the yoke element that releasably receives the middle umbilicus region for rotation about the rotational axis, and

a rotating third holder on the processing chamber that releasably receives the lower umbilicus region for rotation about the second axis.

8. A centrifuge according to claim 7

wherein the first holder is moveable between a first position holding the upper umbilicus region adjacent to the processing chamber for conducting fluid when the cross member is in the operating position and a second position free of the upper umbilicus region and spaced away from the processing chamber for allowing access when in the access position.

9. A centrifuge according to claim 8

wherein the third holder is exposed to access for receiving and releasing the lower umbilicus region when the cross member is in the access position.

10. A centrifuge according to claim 7

and further including a processing element that communicates with the lower umbilicus region, the processing element being carried within the processing chamber and being removable therefrom when the spool and bowl elements are in their mutually separated position.

11. A centrifuge comprising

a frame enclosing an interior area and including at least one weight bearing member for engaging a support surface lying in the horizontal plane,

a centrifuge assembly including

a yoke element including a base, a pair of arms extending from the base defining a space between the arms, and a cross member,

a drive mechanism coupled to the base of the yoke element to rotate the yoke element about a rotational axis,

a processing chamber mounted on the cross member for rotation about a second axis, and

a hinge coupling the cross member to one of the arms for pivoting the cross member about the hinge between an operating position, in which the cross member extends across the space between the arms, and an access position, in which the cross member is cantilevered from the hinge outside the space between the arms, the hinge, when in the operating position, orienting the processing chamber in the space between the arms with the second axis aligned generally coaxial with the rotational axis, orienting the processing chamber for centrifugal processing during rotation of the yoke element, the hinge, when in the access position, orienting the processing chamber outside the space between the arms with the second axis lying outside the axis of rotation, orienting the processing chamber for access by the user, and

a base supporting the centrifuge assembly on the frame within the interior area with the rotational axis oriented in a plane that lies outside a vertical plane perpendicular to the horizontal plane.

12. A centrifuge according to claim 11

wherein, when the cross member is in the access position, the second axis is oriented in a generally perpendicular relationship to the horizontal plane.

13. A centrifuge according to claim 11 or 12

wherein the processing chamber includes a surface region having means for accessing the interior of the processing chamber, and

wherein, when the cross member is in the operating position, the accessing means is generally oriented toward the support surface, and, when the cross member is in the access position, the accessing means is generally oriented away from the support surface.

14. A centrifuge according to claim 11 or 12

wherein the processing chamber includes a bowl element having an interior area, a spool element having an exterior surface, and means for joining the spool and bowl elements for movement between a mutually cooperating position, in which the spool element is enclosed within the interior area of the bowl element to define the processing chamber between the bowl wall and the exterior spool surface, and a mutually separated position, in which the spool element is at least partially out of the interior area of the bowl element to expose the exterior spool surface for access.

15. A centrifuge according to claim 14

wherein the spool element includes means exposed when the spool and bowl elements are in the mutually separated position for receiving a processing element upon the spool exterior surface and for retaining the processing element within the processing chamber when the spool and bowl elements are moved to the mutually cooperating position.

16. A system according to claim 11

wherein the plane in which the rotational axis of the yoke member lies extends at about a 45°

angle with respect to the horizontal plane.

17. A system according to claim 11

and further including a door supported on the frame that opens to provide access to the interior area and that closes to block access to the interior area,

wherein the base supports the centrifuge assembly such that the processing chamber lies adjacent to the door, whereby opening the door provides access to the processing chamber, and

wherein, when the cross member is in the operating position, it is located within the interior area and, when the cross member is in the access position, the processing chamber extends at least partially outside the interior area through the open door.

18. A centrifuge according to claim 17

wherein, when the cross member is in the access position, the second axis is oriented in a generally perpendicular relationship to the horizontal plane.