Recombinant cytomegalovirus vaccine
First Claim
Patent Images
1. A non-defective recombinant adenovirus containing a fragment of the gB gene selected from the group consisting of (a) the gB gene fragment encoding amino acid 1 to amino acid 700 of human cytomegalovirus gB subunit protein SEQ ID NO:
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
2, said gB gene fragment being under the control of an expression control sequence, said adenovirus capable of expressing said subunit protein fragment.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides a non-defective adenovirus recombinant expression system for the expression of the HCMV gB subunit, an immunogenic fragment of the gB subunit, and for the expression of non-structural immediate-early exon 4 proteins, said recombinant HCMV-expressing adenovirus being useful as a vaccine.
10 Citations
19 Claims
-
1. A non-defective recombinant adenovirus containing a fragment of the gB gene selected from the group consisting of (a) the gB gene fragment encoding amino acid 1 to amino acid 700 of human cytomegalovirus gB subunit protein SEQ ID NO:
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
2, said gB gene fragment being under the control of an expression control sequence, said adenovirus capable of expressing said subunit protein fragment. - View Dependent Claims (2, 3, 4, 5)
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
-
6. A cytomegalovirus immunogenic composition comprising a non-defective recombinant adenovirus and suitable pharmaceutical carrier, wherein said recombinant adenovirus contains a fragment of the gB gene selected from the group consisting of (a) the gB gene fragment encoding amino acid 1 to amino acid 700 of human cytomegalovirus gB subunit protein SEQ ID NO:
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to amino acid 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
2, said gene fragment being under the control of an expression control sequence, said adenovirus capable of expressing said subunit protein fragment. - View Dependent Claims (7, 8, 9, 10, 11, 12)
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to amino acid 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
-
13. A method for eliciting an immune response against human cytomegalovirus in an animal comprising administering an effective amount of a cytomegalovirus immunogenic composition comprising a non-defective recombinant adenovirus and suitable pharmaceutical carrier, wherein said recombinant adenovirus contains a fragment of the gB gene selected from the group consisting of (a) the gB gene fragment encoding amino acid 1 to amino acid 700 of human cytomegalovirus gB subunit protein SEQ ID NO:
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to amino acid 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
2, said gene fragment being under the control of an expression control sequence, said adenovirus capable of expressing said subunit protein fragment. - View Dependent Claims (14, 15, 16, 17, 18, 19)
- 2 and (b) smaller fragments thereof, said smaller fragments comprising the gB gene fragment encoding amino acid 155 to amino acid 303 of human cytomegalovirus gB subunit protein SEQ ID NO;
Specification