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Nucleoside derivatives

  • US 5,552,540 A
  • Filed: 05/27/1993
  • Issued: 09/03/1996
  • Est. Priority Date: 06/24/1987
  • Status: Expired due to Term
First Claim
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1. A nucleoside of the formula (I):

  • ##STR18## wherein (A) Y is H, OH or a protected hydroxy group;

    (B) X is H, a phosphonate group or a phosphoramidite group of the formula ##STR19## wherein (i) R1 and R2 are the same or different, and are selected from branched or unbranched C1-30 alkyl or substituted C1-30 alkyl having substituents selected from the group consisting of phenyl, benzyl, acyl, methyl, propyl, ethyl, isopropyl and butyl; and

    (ii) Q is a phosphate protecting group;

    (C) Z is H, a phosphate group, a triphosphate group or a hydroxy-protecting group;

    (D) X'"'"' is a branched or unbranched C1-15 alkyl group;

    (E) R is an acid labile amino protecting group, an amino reactive detectable marker, or the group
    
    
    space="preserve" listing-type="equation">Y'"'"'NHA,wherein(i) Y'"'"' is a branched or unbranched C1-40 alkyl carbonyl group; and

    (ii) A is an acid labile amino protecting group, or an amino reactive detectable marker.

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