Method and apparatus for administration of contrast agents for use in magnetic resonance arteriography

• US 5,553,619 A
• Filed: 01/25/1995
• Issued: 09/10/1996
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Casler, Brian L.
• Application Number:
  US08/378,384
• Time in Patent Office: 594 Days
• Field of Search: 128/653.3, 128/653.4, 128/654, 128/655, 128/659, 424/9.3, 424/9.36, 324/37, 324/309
• US Class Current: 600/420
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

Claims

1. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a magnetic resonance contrast agent to the patient prior to collecting image data, by intravenous infusion, at a rate of infusion sufficient to provide a substantially elevated concentration of the contrast agent in the artery during collection of image data representative of a center of k-space.

2. The method of claim 1 wherein the step of administering the contrast agent to the patient further includes administering a paramagnetic contrast agent at a rate of infusion which is greater than 0.0015 Liters/Kg-sec² divided by a relaxivity of the paramagnetic contrast agent.

3. The method of claim 1 wherein the step of administering the contrast agent to the patient further includes administering the contrast agent at an infustion rate and for a perid which proivdes a substantially elevated concentration of the magnetic resonance contrast agent in the artery during more than 50% of the period of collecting image data representative of the center of k-space.

4. The method of claim 1 wherein the step of administering the contrast agent to the patient further includes administering the contrast agent at a infusion rate which is sufficient to provide an increase in a signal intensity from the artery of greater than about a factor of 2 during collection of at least a morton of the image ata representative of the center of k-space.

5. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a magnetic resonance contrast agent to the patient while collecting image data, by intravenous infusion, at a rate of infusion sufficient to provide a substantially elevated concentration of the contrast agent in artery relative to adjacent veins during collection of image data corresponding to a center of k-space.

6. The method of claim 5 wherein the step of administering the contrast agent to the patient further includes administering the contrast agent for a period sufficient to provide a substantially elevated concentration of the magnetic resonance contrast agent in the artery for at least 50% of the period of collecting image data corresponding to the center of k-space.

7. The method of claim 5 wherein the step of administering the contract agent to the patient further includes administering the contrast agent at a rate which is sufficient to provide an increase in a signal intensity from the artery of greater than about a factor of 2 during collection of at least a portion of the image data representative of the center of k-space.

8. The method of claim 5 wherein the step of administering magnetic resonance contrast agent includes administering the contrast using a mechanical injector which is one of a spring-loaded, a pneumatic powered, and an electrically powered.

9. The method of claim 5 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector wherein the mechanical injector includes a non-magnetic spring to pressurize the contrast agent for infusion into the patient.

10. The method of claim 5 wherein the step of administering a magnetic resonance contrast agent includes administering a gadolinium chelate using a mechanical injector which is adapted to receive a vessel containing the gadolinium chelate wherein the mechanical injector includes a non-magnetic spring.

11. A method of imaging an artery in a patient using a gadolinium chelate, comprising,

collecting image data;

and p1 administering the gadolinium chelate to the patietn, by intravenous infusion, at a rate of infusion which provideds a maximum concentration of the gadolinium chelate in an artery relative to the adjacent veins during collection of image data corresponding to a center of k-spae.

12. The method of claim 11 wherein the step of administering the gadolinium chelate further includes administering the gadolinium chelate at a rate of infusion which is greater than 0.0015 Liters/Kg-sec² divided by a relaxivity of the gadolinium chelate.

13. A method for administering a magnetic resonance contrast agent into a vein of a patient to enhance a magnetic resonance image of an artery of the patient, the method including:

collecting image data; and

administering the contrast agent into the vein at an infusion rate and for a period of time sufficient to provide a maximum concentration of the contrast agent in the artery during collection of at least a portion of the image data which corresponds to a center of k-space.

14. The method of claim 18 wherein the step of administering the contrast agent to the patient further includes administering a paramagnetic contrast agent at a rate of infusion which is greater than 0.0015 Liters/Kg-sec² divided by a relaxivity of the contrast agent.

15. The method of claim 13 wherein the step of administering the contrast agent to the patient further includes administering the contrast agent at a rate which is sufficient to provide an increase in a signal intensity from the artery of greater than about a factor of 2 during collection of at least a portion of the image data representative of the center of k-space.

16. The method of claim 15 wherein the step of administering the contrast agent to the patient further includes administering the contrast aent at an infusion rate which provides a substantially elevated concentration of the magnetic resonance contrast agent in the artery relative to adjacent veins for at least 50 % of the time of the step of collecting image data corresponding to the center of k-space.

17. The method of claim 13 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector which is one of a spring-loaded, a pneumatic powered, and an electrically powered.

18. The method of claim 13 wherein the step of administering a magnetic resonance contrast agent includes administering a gadolinium chelate using a mechanical injector which is adapted to receive a vessel containing the gadolinium chelate wherein the mechanical injector includes a non-magnetic spring to pressurize the contrast for infusion into the patient.

19. The method of claim 18 wherein the step of administering the contrast agent to the patient further includes administering gadolinium chelate at a rate of infusion which is greater than 0.0015 Liters/Kg-sec² divided by a relaxivity of the contrast agent.

20. An apparatus for administering a magnetic resonance contrast agent into a vein of a patient to enhance a magnetic resonance image of an artery of the patient, the apparatus comprises:

an infusion mechanism, including infusion means for matching an infusion rate with a mapping of at least a portion of k-space and for infusing the contrast agent at rate sufficient to provide a substantially elevated concentration of the contrast agent in the artery during collection of at least a portion of image data which corresponds to a center of k-space.

21. The apparatus of claim 20 wherein the infusion means infuses the contrast agent at a rate which provides a substantially elevated concentration of a contrast agent in the artery for at least 50% of a period of collecting image data which corresponds to the center of k-space.

22. The apparatus of claim 20 wherein the infusion means is coupled to a container having the magnetic resonance contrast agent contained therein.

23. The apparatus of claim 22 wherein the container includes an orifice and wherein the apparatus further includes fluid flow restrictor coupled to the orifice.

24. The apparatus of claim 20 wherein the infusion means infuses the contrast agent into the patient at a rate which provides an increase in a signal intensity from the artery of greter than about a factor of 2 during collection of at least a portion of the image data representative of the center of k-space.

25. A method of imaging an artery in a patient using magnetic resonance imaging, comprising:

administering a magnetic resonance contrast agent to the patient; and

collecting image data which is representative of a center of k-space when a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in veins adjacent to the artery.

26. The method of claim 25 wherein the step of collecting image data includes using a 3D gradient echo pulse sequence.

27. The method of claim 26 wherein the step of collecting image data includes using a TR of less than 50 milliseconds, a TE of less than 10 milliseconds, and a flip angle within a range of about 20 to about 90 degrees.

28. The method of claim 25 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient by bolus injection.

29. The method of claim 25 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient substantially throughout collecting image data which is representative of a center of k-space.

30. The method of claim 25 wherein the step of collecting data which is representative of a center of k-space includes collecting data when the concentration of the contrast agent in the artery is above a predetermined level.

31. The method of claim 25 wherein the step of collecting data which is representative of the center of k-space includes collecting at least a portion of the data when a signal intensity from the artery increases by a factor of greater than about 2.

32. The method of claim 25 wherein the step of collecting data which is representative of a center of k-space includes collecting at least 50% of the data which is representative of the center of k-space while the concentration of contrast agent in the artery is substantially higher than the concentration of the contrast agent in veins adjacent to the artery.

33. The method of claim 25 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector which is one of a spring-loaded, a pneumatic powered, and an electrically powered.

34. A method of imaging at least a portion of an artery in a patient using magnetic resonance imaging comprising, performing a 3D gradient echo pulse sequence to obtain an image of the artery, including,

administering a magnetic resonance contrast agent to the patient;

and

collecting image data for imaging the artery including collecting data which is representative of a center of k-space when a concentration of the contrast agent in the artery is substantially elevated.

35. The method of claim 34 wherein the step of collecting image data for imaging the artery includes collecting data which is representative of the center of k-space when the concentration of the contrast agent in the artery is above a predetermined level.

36. The method of claim 34 wherein the step of collecting image data includes using a TR of less than 50 milliseconds, a TE of less than 10 milliseconds, and a flip angle within a range of about 20 to about 90 degrees.

37. The method of claim 34 wherein the step of collecting image data includes collecting at least 50% of the data which is representative of the center of k-space while the concentration of contrast agent in the artery is substantially elevated.

38. The method of claim 34 wherein the step of collecting image data includes collecting at least a portion of the image data while a signal intensity from the artery increases by a factor of greater than about 2.

39. A method of imaging a portion of an artery in a patient using magnetic resonance imaging, said method comprising,

administering a magnetic resonance contrast agent to the patient;

and

collecting a portion of image data which is representative of a center of k-space while a concentration of the contrast agent in the artery is substantially elevated.

40. The method of claim 39 wherein the step of administering a magnetic resonance contrast agent to the patient includes administering the contrast agent to the patient by a bolus injection.

41. The method of claim 39 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient substantially throughout collecting image data which is representative of a center of k-space.

42. The method of claim 39 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data when the concentration of the contrast agent in the artery is a maximum.

43. The method of claim 39 wherein the step of collecting image data which is representative of the center of k-space includes collecting at least a portion of the image data while a signal intensity from the artery increases by a factor of greater than about 2.

44. The method of claim 39 wherein the step of collecting data which is representative of the center of k-space includes using a 3D gradient echo pulse sequence and the step of administering a magnetic resonance contrast agent to the patient includes administering the contrast agent to the patient by a bolus injection.

45. The method of claim 44 wherein the step of collecting data includes using a TR of less than 50 milliseconds, a TE of less than 10 milliseconds, and a flip angle within a range of about 20 to about 90 degrees.

46. The method of claim 39 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient at a variable rate of injection.

47. The method of claim 39 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient during collection of magnetic resonance image data.

48. The method of claim 39 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient manually through a fluid flow restrictor.

49. The method of claim 39 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient using a mechanical injector.

50. The method of claim 39 wherein the step of collecting the image data which is representative of the center of k-space includes collecting at least a portion of the data while a signal from an imaging region increases by more than about 20%.

51. The method of claim 39 wherein the step of collecting the image data which is representative of the center of k-space includes collecting at least a portion of the data while a signal from an imaging region increases by more than about 50%.