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Renewable neural implant device and method

  • US 5,554,148 A
  • Filed: 05/26/1995
  • Issued: 09/10/1996
  • Est. Priority Date: 11/17/1987
  • Status: Expired due to Term
First Claim
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1. A refillable immunoisolatory therapeutic device for implantation through a human skull and into a human brain, comprising:

  • an outer flexible cell chamber adapted for containing viable cells which secrete at least one biologically active factor, the outer cell chamber having a first end connected to a cap, a second end for positioning within the brain, and at least one semipermeable surface across which the active factor secreted by the viable cells can be delivered at ambient pressure to the brain, the cell chamber being adapted for infusion with the viable cells and for protecting the cells from immunogens,an inner flushing duct with a proximal end and a distal end, the distal end open to the second end of the cell chamber,the cap adapted to engage an anchoring means, for anchoring the cell chamber and the inner flushing duct to the human skull, the cap having accessing means for accessing the cell chamber and the inner flushing duct to introduce, flush and renew the viable cells,the accessing means comprising an inner flushing duct port and an outer cell chamber port, the flushing duct port in fluid communication with the proximal end of the inner flushing duct, and the outer cell chamber port in fluid communication with the first end of the outer cell chamber,a mandrel to protect the cell chamber.

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