Production of recombinant human interferon-beta.sub.2
First Claim
1. A recombinant vector comprising a DNA sequence which codes for human interferon-beta2.sbsb.A and further comprising a regulatory region positioned in a way that expression of the human interferon beta2.sbsb.A is possible.
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Abstract
Human interferon-beta2.sbsb.A and interferon-beta2.sbsb.B are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the production of IFN-β2.sbsb.A and IFN-β2.sbsb.B, respectively. The sequence of IFN-β2.sbsb.A cDNA is established. These genes and cDNA have been cloned into mammalian cells with an SV40 early promoter sequence and such genomic clones are capable of producing IFN-β2.sbsb.A and IFN-β2.sbsb.B. The anti-viral activity of such recombinant IFN-β2.sbsb.A and IFN-β2.sbsb.B is demonstrated as well as other biological activity identifying them as human interferons.
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Citations
24 Claims
- 1. A recombinant vector comprising a DNA sequence which codes for human interferon-beta2.sbsb.A and further comprising a regulatory region positioned in a way that expression of the human interferon beta2.sbsb.A is possible.
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22. A non-human cell, containing a human gene consisting essentially of the human interferon-β
- 2A gene.
- View Dependent Claims (23, 24)
Specification