Methods for neuroprotection
First Claim
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1. A method of conferring neuroprotection on a population of cells in a subject, comprising:
- (i) providing an estrogen compound; and
(ii) administering the compound in the absence of testosterone, in an effective dose, to the population of cells so as to confer neuroprotection.
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Abstract
A method is provided for conferring neuroprotection on a population of cells using estrogen compounds that have insubstantial sex activity and furthermore, a method is provided that utilizes estrogen compounds in the absence of testosterone for treating neurodegenerative diseases including Alzheimer'"'"'s disease so as to retard the adverse effects of these disorders, Examples of estrogen compounds that have insubstantial sex activity includes alpha isomers of estrogen compounds such as 17α estradiol.
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Citations
29 Claims
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1. A method of conferring neuroprotection on a population of cells in a subject, comprising:
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(i) providing an estrogen compound; and (ii) administering the compound in the absence of testosterone, in an effective dose, to the population of cells so as to confer neuroprotection. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 29)
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23. A method of treating a neurodegenerative disorder in a subject, comprising;
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(i) providing an effective dose of an estrogen compound, in a pharmaceutical formulation; and (ii) administering the formulation in the absence of testosterone, to the subject so as to retard adverse effects of the disorder. - View Dependent Claims (24, 26)
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25. A method of treating a neurodegenerative disorder in a male subject, comprising:
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(i) providing an effective dose of an estrogen compound in a pharmaceutical formulation; and (ii) administering the formulation to the subject so as to retard adverse effects of the disorder. - View Dependent Claims (27)
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28. A method of conferring neuroprotection on a population of cells in a subject, comprising:
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(i) providing an estrogen compound having insubstantial sex-related activity, in a pharmaceutical formulation; and (ii) administering the formulation in an effective dose to the population of cells to confer neuroprotection.
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Specification