Independent photoelectric artificial retina device and method of using same

• US 5,556,423 A
• Filed: 04/20/1994
• Issued: 09/17/1996
• Est. Priority Date: 05/03/1993
• Status: Expired due to Term

• Current Assignee: IMI Intelligent Medical Implants AG (Pixium Vision SA)
• Original Assignee: Alan Y. Chow
• Inventors: Chow, Alan Y., Chow, Vincent
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/230,504
• Time in Patent Office: 881 Days
• Field of Search: 607/53, 607/54, 607/116, 607/141, 623/4, 623/5, 623/24, 128/898
• US Class Current: 623/6.63
• CPC Class Codes: A61F 9/00727 Apparatus for retinal reattachment
• CPC Class Codes: A61F 9/08 Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: H01L 27/14643 Photodiode arrays; MOS imagers

Abstract

Microscopic photodiode devices with semi-transparent surface electrodes are combined with a liquid or other suitable vehicle. Together they are injected into the subretinal space of the eye. The purpose of these microphotodiode photovoltaic devices is to transduce incident light into electric current which stimulate the overlying cellular layers of the retina. In persons suffering from visual dysfunction due to outer retinal layer damage, such devices may allow useful formed artificial vision. These independent surface electrode microphotodiodes (ISEMCPs) may be in the shape of micro-spheres, micro-cylinders or other micro-shapes. An off-center embedded ferromagnetic layer will confer magnetic susceptibility to the ISEMCPs. A magnetic field applied in the vicinity of the eye will align the ISEMCPs within the subretinal space directing their photoactive surface toward incident light. Alternatively ISEMCPs may be embedded, prealigned, in a transparent flexible sheet permeable to nutrients and oxygen before implantation into the subretinal space. Such a sheet will allow passage of biological nutrients and oxygen around the ISEMCPs. This sheet may also dissolve leaving behind ISEMCP units lying separately, or in an arranged pattern produced by a surrounding mesh. ISEMCPs may be of the PiN or NiP type or a combination of both in a single unit. An electric capacitor layer may also be incorporated into the ISEMCP device (ISEMCP-C) to allow charge storage during exposure to light and charge release in darkness producing an opposite polarity current. This last modification will allow the generation of hyperpolarizing currents in light and depolarizing currents in darkness which is necessary to produce formed vision of light and dark images.

Claims

1. A method of producing artificially formed vision in an eye, comprising the step of introducing a plurality of discrete microscopic photoelectric devices into the subretinal space of the eye wherein at least some of said photoelectric devices include a capacitative storage element that produces opposite direction electrical currents in light and darkness, permitting formed vision of light and dark images as a result of light and dark images received by the retina.

2. The method defined in claim 1, wherein said plurality of discrete microscopic photoelectric devices are introduced as discrete microphotodiodes.

3. The method defined in claim 2, wherein said plurality of discrete microphotodiodes are introduced as P-i-N semiconductors.

4. The method defined in claim 2, wherein said plurality of discrete microphotodiodes are introduced as N-i-P semiconductors.

5. The method defined in claim 2, further comprising the steps of suspending the plurality of microphotodiodes in a liquid, and injecting the resulting suspension into the subretinal space.

6. The method defined in claim 5, wherein the plurality of microphotodiodes are introduced by a canula for implantation into the subretinal space.

7. The method defined in claim 6, wherein the plurality of microphotodiodes are introduced into the vitreous cavity by creation of a pars plana incision.

8. The method defined in claim 7, wherein the posterior vitreous is dissected to separate the posterior hyaloid face from the retinal surface, and an incision is made through the retina and into the subretinal space.

9. The method defined in claim 8, wherein the subretinal space is entered with a small retinotomy incision along the direction of the nerve fiber layer, followed by dissection of the inner retina from the outer retina.

10. The method defined in claim 5, wherein the liquid comprises a balanced salt solution.

11. The method defined in claim 5, wherein the liquid comprises a viscous agent.

12. The method defined in claim 11, wherein the viscous agent comprises methylcellulose.

13. The method defined in claim 5, further comprising the steps of injecting a liquid that is non-miscible in water over the posterior pole in the vitreous cavity of the eye after the suspension is injected to aid in the settling of the retina, and then removing the non-miscible liquid after the retina is settled.

14. The method defined in claim 13, wherein the non-miscible liquid comprises perfluorocarbon.

15. The method defined in claim 13, wherein the non-miscible liquid is removed an appropriate time period after it has been injected.

16. The method defined in claim 1, further comprising the step of aligning the microphotodiodes to receive light incident upon the eye.

17. The method defined in claim 16, wherein the microphotodiodes are aligned with a magnetic field.

18. A light powered artificial subretinal implant device comprising a carrier vehicle and a plurality of discrete photoelectric devices, wherein each photoelectric device comprises a photo-active surface and a corresponding first electrode disposed on the photoelectric device, a second electrode disposed on the photoelectric device spaced from the first electrode, and a capacitive storage element disposed on the photoelectric device and electrically connected to the second electrode to store electric charge generated by the photoelectric device in light conditions and to release electric charge in dark conditions to permit formed vision of light and dark images.

19. The artificial subretinal implant device defined in claim 18, wherein the plurality of discrete photoelectric devices comprise discrete independent surface electrode microphotodiodes.

20. The artificial subretinal implant device defined in claim 19, wherein the independent surface electrode microphotodiodes comprise P-i-N semiconductors.

21. The artificial subretinal implant device defined in claim 19, wherein the independent surface electrode microphotodiodes comprise N-i-P semiconductors.

22. The artificial subretinal implant device defined in claim 19, wherein the first electrode is semitransparent.

23. The artificial subretinal implant device defined in claim 19, wherein the first electrode conducts electric current and allows passage of light through it.

24. The artificial subretinal implant device defined in claim 19, wherein the first electrode is fabricated from the group consisting of polysilicon, gold, chromium, iridium, aluminum and platinum.

25. The artificial subretinal implant device defined in claim 19, wherein the first electrode covers a fraction of the photo-active surface of the microphotodiodes.

26. The artificial subretinal implant device defined in claim 19, wherein the microphotodiodes comprise a substantially spherical shape.

27. The artificial subretinal implant device defined in claim 19, wherein the microphotodiodes comprise a cylindrical or rod-like shape.

28. The artificial subretinal implant device defined in claim 19, further comprising a magnetically susceptible layer, in each photoelectric device wherein the magnetically susceptible layer facilitates alignment of the microphotodiodes in the subretinal space by application of an external magnetic field and comprises a substance from the group consisting of palladium, tungsten, cobalt, nickel, nickel alloy, iron, iron alloy, samarium, and magnetically susceptible ceramics.

29. The artificial subretinal implant device defined in claim 19, wherein the carrier vehicle comprises a liquid.

30. The artificial subretinal implant device defined in claim 19, wherein the carrier vehicle comprises a viscous material.

31. The artificial subretinal implant device defined in claim 19, wherein said carrier vehicle comprises a sheet of oxygen and nutrient permeable material, wherein the plurality of discrete photoelectric devices are embedded in the sheet, and wherein the discrete devices are placed in the sheet and pre-aligned to incident light.

32. The artificial retinal implant device defined in claim 31, wherein the sheet of oxygen and nutrient permeable material comprises a non-dissolvable material.

33. The artificial retinal implant device defined in claim 32, wherein the non-dissolvable material comprises a hydrophilic polymer of poly (2-hyroxyethylmethacrylate).

34. The artificial retinal implant device defined in claim 31, wherein the sheet of oxygen and nutrient permeable material comprises a dissolvable material.

35. The artificial retinal implant device defined in claim 34, wherein the dissolvable material comprises agar.

36. The artificial retinal implant device defined in claim 34, wherein the dissolvable material comprises collagen.

37. The artificial retinal implant device defined in claim 19, wherein individual microphotodiodes are embedded in a mesh-like network made of an inert substance.

38. The artificial retinal implant device defined in claim 37, wherein the mesh-like network comprises nylon.

39. The artificial retinal implant device defined in claim 37, wherein the mesh-like network comprises polypropylene.