Structures with field responsive permeation control

• US 5,556,528 A
• Filed: 05/10/1994
• Issued: 09/17/1996
• Est. Priority Date: 05/10/1994
• Status: Expired due to Fees

• Current Assignee: Biotechnology Research And Development Corporation (Dow, Inc.)
• Original Assignee: Biotechnology Research And Development Corporation (Dow, Inc.)
• Inventors: Lu, Wenyuan, Bohn, Paul W.
• Primary Examiner(s): Gorgos, Kathryn
• Assistant Examiner(s): Starsiak, Jr., John S.
• Application Number:
  US08/240,244
• Time in Patent Office: 861 Days
• Field of Search: 204/299 R, 204/193, 204/301, 204/180.1, 204/600, 204/450, 204/518, 204/627
• US Class Current: 204/600
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: G01N 27/4473 by electric means

Abstract

Devices are useful to capture or dispense target molecules and include an electric field-responsive valve unit. The valve unit includes an active control structure having at least one monomolecular layer and being up to about 10 nm thick. The active control structure is formed by a majority of molecular species with a dipolar moment greater than about 5 Debye, and operable in response to an electric field at a threshold value. A particularly preferred embodiment has the active control structure carried on a microporous membrane with pores in the nanometer range. Applications for inventive embodiments include drug delivery and target molecule capture during electrophoresis separations.

Claims

1. An electric-field responsive assembly useful with target molecules, comprising:

a fluid source with target molecules therein;

a fluid reservoir spaced from the fluid source, the source, and the reservoir defining a fluid passageway therebetween;

a support being interposed in the passageway, the support permitting target molecules to diffuse therethrough; and

at least one monomolecular layer carried on a surface of the support, the one and any additional monomolecular layers together forming an active control structure, at least one layer of the active control structure is an admixture of molecular species, at least a majority of the molecular species having a large ground state dipole moment, each monomolecular layer having closely packed, dipolar molecules that are substantially aligned along their long axes, the active control structure having an average off permeability value for target molecules in the absence of an electric field or in the presence of an electric field below a threshold value, the active control structure having an on permeability value to target molecules when at least the electric field threshold value is applied thereacross, the on permeability value being enhanced with respect to the off permeability value.

2. The assembly as in claim 1 wherein the large ground state dipole moment is above about 5 Debye.

3. The assembly as in claim 1 wherein the admixture includes stilbazolium hemicyanines, stilbene derivatives, thiacyanines, oxacyanines, merocyanines, or isocyanines.

4. The assembly as in claim 1 wherein a minority of molecular species are amphiphilics having a carboxyl, alcohol, quaternary amine, or sulfonate head group.

5. The assembly as in claim 4 wherein the minority amphiphilics have up to about 31 carbon atoms.

6. The assembly as in claim 1 wherein each layer has molecules packed so as to be on the order of a short axis molecular diameter of each other in the absence of the electric field threshold being applied thereacross.

7. The assembly as in claim 1 wherein the enhancement is a permeability rate (cm² s^-1) increased by at least about 20 times.

8. An electric-field responsive assembly useful with target molecules, comprising:

a fluid source with target molecules therein;

a fluid reservoir spaced from the fluid source, the source, and the reservoir defining a fluid passageway therebetween;

a support being interposed in the passageway, the support permitting target molecules to diffuse therethrough, the fluid reservoir and support being a composite structure with the composite structure including a swellable polymer, at least one monomolecular layer carried on a surface of the support, the one and any additional monomolecular layers together forming an active control structure, each monomolecular layer having closely packed, dipolar molecules that aligned along their long axes, the active control structure having an average off permeability value for target molecules in the absence of an electric field or in the presence of an electric field below a threshold value, the active control structure having an on permeability value to target molecules when at least the electric field threshold value is applied thereacross, the on permeability value being enhanced with respect to the off permeability value.

9. The electric-field responsive assembly as in claim 8 wherein the support includes a microporous membrane.

10. The assembly as in claim 9 wherein the microporous membrane includes pores with diameters in the range of about 100 Å

to about 1000 Å

.

11. The assembly as in claim 9 or 10 wherein a polymeric network is disposed between the active control structure and the membrane.

12. The assembly as in claim 11 wherein the polymeric network is bound to the active control structure.

13. A molecular capturing or dispensing device, comprising:

a field-responsive valve unit, the valve unit in fluid communication with a source of target molecules, the valve unit including an active control structure up to about 10 nm thick, the active control structure having at least one monomolecular layer formed by an amphiphilic composition, the amphiphilic composition having a majority of first molecular species with a dipolar moment greater than about 5 Debye, the active control structure being operable in response to an electric field at or about a selected threshold value; and

an electrode assembly operably coupled to the valve unit for delivery of an electric field at or above the selected threshold value.

14. The device as in claim 13 wherein the first molecular species includes stilbazolium hemicyanines, stilbene derivatives, thiacyanines, oxacyanines, merocyanines, or isocyanines.

15. The device as in claim 13 or 14 wherein the amphiphilic composition has a minority of second molecular species admixed therein, the second molecular species having fatty acid tails of from about 12 carbons to about 30 carbons.

16. The device as in claim 15 wherein each monomolecular layer of the active control structure has substantially all the amphiphilic composition molecules packed to within about one molecular diameter with respect to a short axis and having substantially all the molecules of the amphiphilic composition being generally aligned with respect to long axes thereof.

17. The device as in claim 15 wherein the monomolecular layers of the active control structure are in a selectable spatial and orientation order.

18. The molecular capturing or dispensing device as in claim 13 wherein a plurality of field-responsive valve units are each operably coupled to at least one electrode assembly.