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Oligoprobe designstation: a computerized method for designing optimal DNA probes

  • US 5,556,749 A
  • Filed: 11/12/1992
  • Issued: 09/17/1996
  • Est. Priority Date: 11/12/1992
  • Status: Expired due to Fees
First Claim
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1. A programmed computer system for designing optimal oligonucleotide probes for use with a gene sequence data source comprising:

  • first input means for introducing user-selected gene sequences into the computer system;

    memory means for storing user-selected gene sequences;

    means for accessing gene sequence data from said gene sequence data source;

    means for performing hybridization strength modeling on gene sequences which is determined by numbers of matching between gene sequences;

    means for performing hybridization strength modeling on gene sequences which is determined by melting temperature (Tm);

    means for selecting either of said modeling means; and

    means for presenting the results of said modeling to present candidate oligonucleotide probes with a candidate oligonucleotide probe hybridization shown as numbers of hybridizations as compared to said gene sequence data from said gene sequence data source.

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