Blood pulse detection method using autocorrelation

• US 5,558,096 A
• Filed: 07/21/1995
• Issued: 09/24/1996
• Est. Priority Date: 07/21/1995
• Status: Expired due to Term

• Current Assignee: BCI, Inc.
• Original Assignee: Biochem International, Inc.
• Inventors: Palatnik, Eugene S.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): YARNELL, BRYAN KEITH
• Application Number:
  US08/505,502
• Time in Patent Office: 431 Days
• Field of Search: 128/632, 128/633, 128/664-8, 128/672-5, 128/680, 128/687, 128/689, 128/696, 128/706, 364/413.01, 364/413.02, 364/413.05, 356/39, 356/40, 356/41
• US Class Current: 600/500
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence

Abstract

A medical monitor determines the period of a physiological function, such as blood circulation pulses, by operating a probe that produces an electrical signal which corresponds to the physiological function. The electrical signal is digitized at a given sampling rate to acquire a plurality of signal samples which are stored in a memory. A time scaling factor is adjusted dynamically so that the amount of signal samples being processed does not exceed a maximum limit. The magnitude of the signal samples also may be scaled dynamically. Serial autocorrelation is applied to the signal samples to produce a sequence of summation values. The quantity of summation values from the initial one in the sequence to a peak summation value is determined. The physiological function period is derived from the quantity of summation values, the given sampling rate, and any time scaling factor that was used.

Claims

1. A method performed by a medical monitor in order to determine a period of a physiological function of a patient, wherein the method comprises steps of:

operating a probe to produce an electrical signal which represents the physiological function;

periodically sampling the electrical signal at a given sampling rate to acquire a plurality of signal samples X(i), where i is an integer that designates a particular signal sample;

storing the plurality of signal samples in a memory;

applying serial autocorrelation to the plurality of signal samples to produce a sequence of summation values S(n), where n is a positive integer which designates a particular summation value and an order of the summation values in the sequence;

storing the sequence of summation values in the memory;

locating a peak summation value S(max), where max is a positive integer, by;

(a) deriving a threshold value,

(b) locating a first summation value S(ind1) which has a magnitude that is less than the threshold value and where ind1 is a positive integer,

(c) locating a second summation value S(ind2) having a magnitude greater than the threshold value and where ind2is a positive integer greater than ind1,

(d) locating a third summation value S(ind3) having a magnitude less than the threshold value and where ind3is a positive integer greater than ind2, and

(e) then locating the peak summation value S(max) as a summation value of greatest magnitude that is between the second and third summation values;

determining a count of summation values in the sequence of summation values from an initial summation value to the peak summation value S(max); and

deriving the period from the count of summation values and the given sampling rate.

2. The method as recited in claim 1 wherein the step of applying serial autocorrelation produces each of the summation values S(n) according to the function:

##EQU4## where f is a scaling factor and k is the amount of signal samples that have been accumulated since a previous reset of the serial autocorrelation.

3. The method as recited in claim 1 further comprising evaluating whether the plurality of signal samples accurately represent the physiological function by producing an invalidity indication if the first summation value S(ind1) is not located.

4. A method performed by a medical monitor in order to determine a period of a physiological function of a patient, wherein the method comprises steps of:

operating a probe to produce an electrical signal which represents the physiological function;

periodically sampling the electrical signal at a given sampling rate to acquire a plurality of signal samples X(i), where i is an integer that designates a particular signal sample;

storing the plurality of signal samples in a memory;

applying serial autocorrelation to the plurality of signal samples to produce a sequence of summation values S(n), where n is a positive integer which designates a particular summation value and an order of the summation values in the sequence;

storing the sequence of summation values in the memory;

locating a peak summation value S(max), where max is a positive integer;

determining a count of summation values in the sequence of summation values from an initial summation value to the peak summation value S(max);

deriving the period from the count of summation values and the given sampling rate;

locating a first summation value S(period1) where period1 is an integer less than max; and

locating a second summation value S(period2) where period2 is an integer greater than max.

5. The method as recited in claim 4 wherein period1 is substantially equal to two-thirds of max;

and period2 is substantially equal to 1.5 times max.

6. The method as recited in claim 4 further comprising deriving a threshold value;

and locating a summation value S(ind1) which is first to occur in the sequence with a magnitude that is less than the threshold value, where ind1 is a positive integer.

7. The method as recited in claim 6 further comprising indicating whether the plurality of signal samples accurately represent the physiological function by producing an invalidity indication when at least one of the following conditions exists:

(a) the summation value S(ind1) could not be located,

(b) a summation value of greatest magnitude between S(ind1) and S(period1) has a magnitude less than the threshold value,

(c) S(period1) is a summation value of greatest magnitude between period1 and period2 inclusive,

(d) S(period2) is the summation value of greatest magnitude between period1 and period2 inclusive, and

(e) the summation value of greatest magnitude between S(period1) and S(period2) inclusive is less than the summation value of greatest magnitude between S(ind1) and S(period1);

otherwise producing a validity indication.

8. The method as recited in claim 7 further comprising incrementing a confidence indication whenever the validity indication is produced, and decrementing the confidence indication whenever the invalidity indication is produced.

9. A method performed by a medical monitor in order to determine a period of a physiological function of a patient, wherein the method comprises steps of:

operating a probe to produce an electrical signal which represents the physiological function;

periodically sampling the electrical signal at a given sampling rate to acquire a plurality of signal samples X (i), where i is an integer that designates a particular signal sample;

storing the plurality of signal samples in a memory;

applying serial autocorrelation to the plurality of signal samples to produce a sequence of summation values S(n), where n is a positive integer which designates a particular summation value and an order of the summation values in the sequence;

storing the sequence of summation values in the memory;

locating a peak summation value S(max), where max is a positive integer;

when the peak summation value S(max) can not be located within a predefined amount of summation values, then increasing a time scaling factor f_T by two, shrinking the sequence of summation values by one-half, and disregarding every other previously acquired signal sample in subsequent production of summation values;

determining a count of summation values in the sequence of summation values from an initial summation value to the peak summation value S(max); and

deriving the period from the count of summation values and the given sampling rate.

10. The method as recited in claim 9 wherein the step of deriving the period comprises the count of summation values multiplied by the given sampling rate divided by the time scaling factor.

11. A method performed by a medical monitor in order to determine a period of a physiological function of a patient, wherein the method comprises steps of:

operating a probe to produce an electrical signal which represents the physiological function;

periodically sampling the electrical signal at a given sampling rate to acquire a plurality of signal samples X(i), where i is an integer that designates a particular signal sample;

storing the plurality of signal samples in a memory;

applying serial autocorrelation to the plurality of signal samples to produce a sequence of summation values S(n), where n is a positive integer which designates a particular summation value and an order of the summation values in the sequence;

storing the sequence of summation values in the memory;

locating a peak summation value S(max), where max is a positive integer;

when a signal sample exceeds a predetermined magnitude, doubling an amplitude scaling factor f_A, dividing each previously acquired signal sample by two, dividing each of the sequence of summation values produced previously by four, and dividing each signal sample acquired thereafter by the amplitude scaling factor f_A ;

determining a count of summation values in the sequence of summation values from an initial summation value to the peak summation value S(max);

deriving the period from the count of summation values and the given sampling rate.

12. The method as recited in claim 11 further comprising, when the peak summation value S(max) can not be located with in a predefined amount of summation values:

increasing a time scaling factor f_T by two;

shrinking the sequence of summation values by one-half; and

disregarding every other previously acquired signal sample in subsequent production of summation values.

13. The method as recited in claim 12 wherein the step of applying serial autocorrelation produces each of the sequence of summation values S(n) according to the function:

##EQU5## where k is the quantity of signal samples that have been accumulated since a previous reset of the serial autocorrelation.

14. A medical apparatus for monitoring a physiological function of a patient, wherein the medical apparatus comprises:

a probe for sensing the physiological function and producing an electrical signal indicative thereof;

a converter connected to said probe to sample the electrical signal at a given sampling rate and produce a plurality of signal samples X(i), where i is an integer that designates a particular signal sample;

a first memory which receives and stores the plurality of signal samples produced by said converter;

a mechanism that applies serial autocorrelation to the plurality of signal samples to produce a sequence of summation values S(n), where n is a positive integer which designates a particular summation value and an order of the summation values in the sequence;

a second memory which stores the sequence of summation values produced by said mechanism;

a means for locating a peak summation value S(max) produced by said mechanism, where max is a positive integer;

a means for determining a count of summation values in the sequence from an initial summation value in the sequence to the peak summation value S(max);

a means for deriving a period of the physiological function from the count of summation values and the given sampling rate;

means for increasing a time scaling factor f_T by two;

means for disregarding every other signal sample stored in the first memory; and

means for shrinking the sequence of summation values stored in the second memory by one-half.

15. The medical apparatus as recited in claim 14 wherein the means for deriving the period multiplies the count of summation values by the given sampling rate divided by the time scaling factor.

16. A medical apparatus for monitoring a physiological function of a patient, wherein the medical apparatus comprises:

a probe for sensing the physiological function and producing an electrical signal indicative thereof;

a converter connected to said probe to sample the electrical signal at a given sampling rate and produce a plurality of signal samples X(i), where i is an integer that designates a particular signal sample;

a first memory which receives and stores the plurality of signal samples produced by said converter;

a mechanism that applies serial autocorrelation to the plurality of signal samples to produce a sequence of summation values S(n), where n is a positive integer which designates a particular summation value and an order of the summation values in the sequence;

a second memory which stores the sequence of summation values produced by said mechanism;

a means for locating a peak summation value S(max) produced by said mechanism, where max is a positive integer;

a means for determining a count of summation values in the sequence from an initial summation value in the sequence to the peak summation value S(max);

a means for deriving a period of the physiological function from the count of summation values and the given sampling rate;

means for doubling an amplitude scaling factor f_A ;

means for dividing each signal sample stored in said first memory by two;

means for dividing each summation value stored in said second memory by four; and

means for dividing each signal sample from the converter by the amplitude scaling factor f_A.

17. The medical apparatus as recited in claim 16 further comprising:

means for increasing a time scaling factor f_T by two;

means for disregarding every other signal sample stored in the first memory; and

means for shrinking the sequence of summation values stored in the second memory by one-half.

18. The medical apparatus method as recited in claim 17 wherein the step of applying serial autocorrelation produces each of the sequence of summation values S(n) according to the function:

##EQU6## where k is a count of signal samples stored in said first memory.