Combretastatin A-4 prodrug
First Claim
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1. A compound having the general structure set forth below:
- ##STR4## wherein R is ##STR5##
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Accused Products
Abstract
Disclosed herein are Combretastatin A-4 Prodrugs, having the general strure set forth below, which are useful in the treatment of one or more neoplastic diseases by means of chemotherapy. ##STR1##
105 Citations
3 Claims
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1. A compound having the general structure set forth below:
- ##STR4## wherein R is ##STR5##
- 2. A method of treating cells afflicted with a neoplastic disease comprising administering to said cells an effective amount of the active ingredient disodium combretastatin A-4 3-O-phosphate in a pharmacologically acceptable carrier.
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Current AssigneeArizona Board of Regents (University of Arizona)
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Original AssigneeArizona Board of Regents (University of Arizona)
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InventorsPettit, George R.
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Primary Examiner(s)Richter, Johann
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Assistant Examiner(s)STOCKTON, LAURA LYNNE
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Application NumberUS08/363,406Time in Patent Office649 DaysField of Search558/210, 514/130US Class Current514/130CPC Class CodesC07F 9/12 with hydroxyaryl compounds
