Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
First Claim
Patent Images
1. A method for pulmonary delivery of a biological agent, comprising the steps of:
- providing a substantially homoqeneous liquid carrier comprising a fluorocarbon liquid;
suspending an immiscible biological agent in said liquid carrier; and
delivering said liquid carrier containing said biological agent through a human or animal'"'"'s pulmonary air passages.
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Abstract
An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
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Citations
17 Claims
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1. A method for pulmonary delivery of a biological agent, comprising the steps of:
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providing a substantially homoqeneous liquid carrier comprising a fluorocarbon liquid; suspending an immiscible biological agent in said liquid carrier; and delivering said liquid carrier containing said biological agent through a human or animal'"'"'s pulmonary air passages. - View Dependent Claims (2, 3)
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4. A method for delivering a biological agent into a human or animal'"'"'s pulmonary system through the human or animal'"'"'s pulmonary air passages comprising the steps of:
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a) providing an apparatus for delivery of a biological agent comprising a conduit having a proximal end adapted to receive a liquid carrier flow, at least one lumen defining a liquid carrier flow path within the conduit, a distal delivery end adapted for delivering the liquid carrier flow to a device that provides liquid communication to pulmonary air passages, a mechanical means for dispersing a biological agent in the liquid carrier flow path within the conduit comprising a plurality of nozzles disposed in spaced array within the liquid carrier flow path wherein each nozzle has a proximal end adapted to receive biological agent and a distal end adapted for delivering the biological agent as a dispersion in the liquid carrier flow; b) introducing the apparatus for delivery of a biological agent into the pulmonary air passages of a human or animal; c) establishing a flow of liquid carrier within the liquid carrier flow path; d) establishing a flow of biological agent through the nozzles thereby dispersing the biological agent within the liquid carrier flow; e) delivering the liquid carrier with dispersed biological agent into the pulmonary air passages of the human or animal. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification