Minute volume rate-responsive pacemaker using dual unipolar leads

• US 5,562,712 A
• Filed: 11/25/1994
• Issued: 10/08/1996
• Est. Priority Date: 11/25/1994
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Dow Corning Corporation (Dow, Inc.)
• Inventors: Steinhaus, Bruce, Lu, Richard, Dawson, Albert
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/345,651
• Time in Patent Office: 683 Days
• Field of Search: 607/20, 607/24, 128/734
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A rate-responsive pacemaker including a pulse generator for providing pacing current pulses at a controlled rate and two unipolar leads are provided. The pulse generator also applies a measuring current between one of the electrodes and a reference point in the pacemaker. The impedance between the other electrode and the reference point is measured across a lung of the patient. The impedance of the patient varies as a function of patient'"'"'s pleural pressure, and therefore, the impedance thus represents the patient'"'"'s minute volume. The rate of pacing is automatically adjusted in response to changes in the patient'"'"'s minute volume.

Claims

1. A rate-responsive pacemaker system comprising:

pulsing means for providing pacing pulses at a controlled rate;

first and second unipolar leads, each having an electrode for coupling respectively to an atrium and a ventricle of a patient;

at least one of said unipolar leads being coupled to said pulsing means for delivering pacing pulses to said patient'"'"'s heart;

means for applying a measuring current between one of said electrodes and a reference point;

means for measuring the impedance between the other of said electrodes and said reference point in response to the application of said measuring current pulse between said one electrode and said reference point, wherein said impedance varies as a function of the patient'"'"'s pleural pressure; and

means for changing said controlled rate in accordance with said impedance.

2. The rate-responsive pacemaker system of claim 1 wherein said measuring current applying means applies said current to the unipolar lead that is coupled to the atrium of the patient'"'"'s heart.

3. The rate-responsive pacemaker system of claim 4 wherein said impedance measuring means is coupled to the unipolar lead that is coupled to the ventricle of the patient'"'"'s heart.

4. The rate-responsive pacemaker system of claim 2 wherein said measuring current is less than one milliamp.

5. The rate-responsive pacemaker of claim 2 wherein said measuring current is 0.1-2.0 milliamps.

6. The rate-responsive pacemaker system of claim 5 wherein said measuring current is applied in pulses.

7. The rate-responsive pacemaker system of claim 1 wherein said reference point is a pacemaker case.

8. A rate-responsive pacemaker system comprising:

pulsing means for providing pacing pulses at a controlled rate;

a first and a second unipolar lead coupled to said pulsing means and having a respective electrode adapted to couple said pulsing means to one of an atrium and a ventricle of a patient'"'"'s heart respectively;

means for deriving a blood impedance signal by injecting selectively a current between one of said electrodes and a reference point and measuring the voltage across said other electrode and said reference point; and

means for adjusting said controlled rate as a function of said impedance signal.

9. The rate-responsive pacemaker system of claim 8 wherein said one of said electrodes is provided for coupling to the atrium of the patient'"'"'s heart.

10. The rate-responsive pacemaker system of claim 9 wherein said other of said electrodes is provided for coupling to the ventricle of the patient'"'"'s heart.

11. The rate-responsive pacemaker system of claim 8 wherein said current is less than one milliamp.

12. The rate-responsive pacemaker system of claim 11 wherein said current is 0.1-2.0 milliamps.

13. The rate-responsive pacemaker system of claim 12 wherein said measuring current is applied in pulses of 1-50 microseconds.

14. The rate-responsive pacemaker system of claim 8 wherein said reference point in said pacemaker system is a pacemaker case.

15. A method of pacing a person'"'"'s heart with a pacemaker system including a pulsing means for providing pacing pulses at a controlled rate, and a first and second unipolar leads, each having a respective electrode, one of said electrodes being secured to the atrium of said patient'"'"'s heart and the other electrode being secured to the ventricle of the patient'"'"'s heart, comprising the steps of:

injecting a current between one of said electrodes and a reference point;

measuring a voltage between the other of said electrodes and said reference point to determine an impedance; and

adjusting said controlled rate in accordance with said impedance.

16. The method of claim 15 wherein said one electrode is attached to said atrium.

17. The method of claim 15 wherein said current is below a milliamp.

18. The method of claim 17 wherein said current is about 0.5 milliamps.

19. The method of claim 15 wherein said current is applied in pulses.

20. The method of claim 19 wherein each pulse has a duration of about 15 microseconds.

21. The method of claim 19 wherein said pulses are applied at a rate of 20 per second.