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Vaccine compositions and method for enhancing an immune response

  • US 5,562,910 A
  • Filed: 09/09/1993
  • Issued: 10/08/1996
  • Est. Priority Date: 09/25/1989
  • Status: Expired due to Fees
First Claim
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1. A method for enhancing an antigen-specific circulating antibody immune response which comprises administering to an individual a vaccine and an effective amount of an immunomodulator as a vaccine adjuvant, said immunomodulator selected from the group consisting of a lymphoid organ modifying agent and a mixture of all immune response augmenting agent and said lymphoid organ modifying agent, said immune response augmenting agent having the formula ##STR3## wherein R1 is ═

  • O;

    R2 is H or halogen;

    R3 is H with a 5-6 double bond;

    R4 is OR5 ;

    R5 is H, SO2 OM, or PO2 OM;

    ##STR4## R6 and R7 may be the same or different and may be a straight or branched C1-14 alkyl, and said lymphoid organ modifying agent is selected from the group consisting of 1,25-dihydroxy Vitamin D3 and all trans-retinoic acid.

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