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Drug incorporating and release polymeric coating for bioprosthesis

  • US 5,562,922 A
  • Filed: 02/07/1995
  • Issued: 10/08/1996
  • Est. Priority Date: 03/18/1993
  • Status: Expired due to Fees
First Claim
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1. A method of making an article for localized delivery of a biologically active compound to a subject, said method comprising:

  • (a) treating a medical-grade, polyurethane polymer coating on a substrate with a coating expansion solution at a temperature, under a pressure and for a time sufficient to cause the biologically active compound to substantially penetrate throughout the entire thickness of the polymer coating,said polymer coating having a thickness of at least 20 microns,said coating expansion solution comprising the biologically active compound and an organic solvent system,wherein the organic solvent system comprises at least one solvent for the polymer coating and at least one non-solvent for the polymer coating, wherein the solvent and the non-solvent are present in the organic solvent system at a ratio of solvent to non-solvent in the range of about 1;

    1 to about 1;

    20 by volume,wherein the biologically active compound is present in the coating expansion solution in a concentration of at least 0.1 parts per 100 parts of the organic solvent system; and

    then(b) drying the thus treated polymer coating to substantially eliminate the organic solvent system.

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