Sterile topical anesthetic gel

• US 5,563,153 A
• Filed: 02/22/1995
• Issued: 10/08/1996
• Est. Priority Date: 02/22/1995
• Status: Expired due to Fees

• Current Assignee: University of Kansas
• Original Assignee: University of Kansas Medical Center
• Inventors: Mueller, David W., Pessetto, James D.
• Primary Examiner(s): Rollins, John W.
• Application Number:
  US08/392,045
• Time in Patent Office: 594 Days
• Field of Search: 514/817, 514/944, 514/535, 514/617, 514/568, 514/312, 514/305, 514/622, 514/652, 514/653, 514/567, 514/816, 514/818
• US Class Current: 514/305
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/245 Amino benzoic acid types, e.g. procaine, novocaine salicylic acid esters A61K31/60
• CPC Class Codes: A61K 31/46 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34

Abstract

The present invention provides a topical anesthetic gel composition, comprising: (a) one or more topical anesthetic agents; (b) an adrenergic sympathomimetic compound; and (c) a pharmaceutical gel component. The present invention also provides a topical anesthetic gel composition, comprising: (a) tetracaine HCl, wherein said tetracaine HCl is contained in said composition in an amount of from about 0.01% to about 1.0% by weight, based upon the total weight of said composition; (b) epinephrine HCl topical solution, wherein said epinephrine HCl is contained in said composition in an amount of from about 0.04% to about 0.1% by weight, based upon the total weight of said composition; (c) cocaine HCl, wherein said cocaine HCl is contained in said composition in an amount of from about 3.0% to about 12.0% by weight, based upon the total weight of said composition; and (d) GELFOAM®, wherein said Gelfoam® is contained in said composition in an amount of from about 6.0% to about 9.0% by weight, based upon the total weight of said composition. Further provided are other topical anesthetic compositions.

Claims

1. A topical anesthetic gel composition comprising,

(a) one or more topical anesthetic agents;

and

(b) a pharmaceutical gel component, wherein said pharmaceutical gel component is Gelfoam®

.

2. The composition of claim 1, wherein said Gelfoam®

is contained in said composition in an amount of from about 6.0% to about 9.0% by weight, based upon the total weight of said composition.

3. A topical anesthetic gel composition, comprising:

(a) tetracaine HCl, wherein said tetracaine HCl is contained in said composition in an amount of from about 0.01% to about 1.0% by weight, based upon the total weight of said composition;

(b) epinephrine HCl topical solution, wherein said epinephrine HCl is contained in said composition in an amount of from about 0.04% to about 0.1% by weight, based upon the total weight of said composition;

(c) cocaine HCl, wherein said cocaine HCl is contained in said composition in an amount of from about 3.0% to about 12.0% by weight, based upon the total weight of said composition; and

(d) GELFOAM®

, wherein said GELFOAM®

is contained in said composition in an amount of from about 6.0% to about 9.0% by weight, based upon the total weight of said composition.

4. A topical anesthetic gel composition, comprising:

(a) lidocaine HCl, wherein said lidocaine HCl is contained in said composition in an amount of from about 0.9% to about 30% by weight, based upon the total weight of said composition;

(b) epinephrine HCl topical solution, wherein said epinephrine HCl is contained in said composition in an amount of from about 0.04% to about 0.1% by weight, based upon the total weight of said composition;

(c) tetracaine HCl, wherein said tetracaine HCl is contained in said composition in an amount of from about 0.01% to about 1.0% by weight, based upon the total weight of said composition; and

(d) GELFOAM®

, wherein said GELFOAM®

is contained in said composition in an amount of from about 6.0% to about 9.0% by weight, based upon the total weight of said composition.

5. A topical anesthetic gel composition, comprising:

(a) lidocaine HCl, wherein said lidocaine HCl is contained in said composition in an amount of from about 0.9% to about 30% by weight, based upon the total weight of said composition; and

(b) GELFOAM®

, wherein said GELFOAM®

is contained in said composition in an amount of from about 6.0% to about 9.0% by weight, based upon the total weight of said composition.