Systems and methods for the synthesis of natural base steroidal hormones and more especially estrogens and progesterone and estrogen-like and progesterone-like compounds and their derivatives derived as phytohormones from herbaceous plants

• US 5,565,199 A
• Filed: 02/07/1995
• Issued: 10/15/1996
• Est. Priority Date: 02/07/1995
• Status: Expired due to Fees

• Current Assignee: Jones Products International, Inc.
• Original Assignee: Elliot W. Page, Linda G. Rector-Page
• Inventors: Rector-Page, Linda G., Page, Elliot W.
• Primary Examiner(s): Rollins, John W.
• Application Number:
  US08/384,914
• Time in Patent Office: 616 Days
• Field of Search: 514/182, 514/874, 424/195.1
• US Class Current: 424/728
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/232 Angelica
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/65 Paeoniaceae (Peony family), e.g. Chinese peony
• CPC Class Codes: A61K 36/71 Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
• CPC Class Codes: A61K 36/74 Rubiaceae (Madder family)
• CPC Class Codes: A61K 36/8945 Dioscorea, e.g. yam, Chinese yam or water yam
• CPC Class Codes: A61K 36/90 Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla

Abstract

Systems and methods for synthesizing natural base steroidal hormones and more especially estrogens and progesterone and estrogen-like and progesterone-like compounds and their derivatives which are derived in the form of phytohormones from herbaceous plants and formulated to provide a broad spectrum of estrogenic and/or progesterone activity for influencing physiological processes and biological functions. In particular, phytohormones (i.e. phytoestrogens and/or phytoprogesterone) are synthesized from herbaceous compounds selected from a group consisting of plants having a propensity for simulating estrogenic and/or progesterone hormonal activity that, when entering the bloodstream of a biological organism, either by means of oral ingestion, parenteral injection, or topical application, have a tendency to enhance, supplement and/or maintain estrogen and/or progesterone hormonal levels by means of replacement therapy within a biological organism.

Claims

1. A process for preparing an active mixture of natural base steroidal hormones for supplementing estrogen and progesterone levels of a biological organism, comprising:

mixing approximately 454 grams of wild yam, approximately 681 grams of sarsaparilla, approximately 681 grams of licorice, approximately 1135 grams of black cohosh, approximately 454 grams of damiana, and approximately 454 grams of dong quai, to obtain a uniform dispersion of said active mixture in a powdered form; and

encapsulating approximately 575 milligrams of said active mixture into a gelatin capsule.

15. A process for preparing an active mixture of natural base steroidal hormones as defined in claim 1 further comprising introducing approximately 454 grams of false unicorn into said active mixture.

16. A process for preparing an active mixture of natural base steroidal hormones as defined in claim 1 further comprising introducing approximately 454 grams of squaw vine into said active mixture.

17. A process for preparing an active mixture of natural base steroidal hormones as defined in claim 1 further comprising replacing said wild yam with approximately 28 grams of blessed thistle.

2. A process for preparing an active mixture of natural base steroidal hormones for supplementing estrogen and progesterone levels of a biological organism, comprising:

mixing approximately 454 grams of wild yam, approximately 681 grams of sarsaparilla, approximately 681 grams of licorice, approximately 1135 grams of black cohosh, approximately 454 dong quai, approximately 454 grams of false unicorn, approximately 454 grams of squaw vine, approximately 454 grams of damiana, approximately 454 grams of raspberry, approximately 454 grams of peony, and approximately 454 grams of burdock, to obtain a uniform dispersion of said active mixture in a powdered form; and

encapsulating approximately 575 milligrams of said active mixture into a gelatin capsule.

3. A process for preparing an active mixture of natural base steroidal hormones as defined in claim 2 further comprising replacing said wild yam with approximately 28 grams of blessed thistle.

4. A process for preparing a gel comprising natural base steroidal hormones for supplementing estrogen and progesterone levels of a biological organism, comprising:

mixing approximately 454 grams of wild yam, approximately 681 grams of sarsaparilla, approximately 681 grams of licorice, approximately 1135 grams of black cohosh, approximately 454 grams of damiana, and approximately 454 grams of dong quai, to obtain a uniform dispersion of an active mixture in a powdered form;

mixing grapeseed oil with a digestible emulsifier until dispersed to obtain a first mixture and heating said first mixture to approximately 80°

C. and then cooling said first mixture to approximately 60°

C.;

mixing distilled water with a vegetable glycerin until dispersed to obtain a second mixture and heating said second mixture to approximately 70°

C. and then cooling said second mixture to approximately 60°

C.;

preparing a gelatinous medium by mixing a cellulose gel with distilled water and allowing said medium to gelatinize;

mixing the first mixture with the second mixture to provide a third mixture;

mixing said active mixture with said third mixture to provide a fourth mixture;

mixing said fourth mixture with said gelatinous medium to form said emulsified gel; and

adjusting a pH of said emulsified gel to accommodate approximately a 6.5 pH balance.

5. A process for preparing a gel comprising natural base steroidal hormones as defined in claim 4 further comprising introducing approximately 454 grams of false unicorn and approximately 454 grams of squaw vine to said active mixture.

6. A process for preparing a gel comprising natural base steroidal hormones as defined in claim 4 further comprises introducing aloe vera juice, licorice phytosomes, and ginseng phytosomes.

7. A process for preparing a gel comprising natural base steroidal hormones as defined in claim 4 wherein adjusting said pH comprises adding an alkaline pH-modifying substance.

8. A process for preparing a gel comprising natural base steroidal hormones as defined in claim 4 further comprising replacing said wild yam with approximately 28 grams of blessed thistle.

9. A process for preparing a gel comprising natural base steroidal hormones as defined in claim 4 further comprising introducing approximately 0.25% of methylparaben and approximately 0.25% of propylparaben into said second mixture.

10. A process for preparing an emulsified gel comprising natural base steroidal hormones for supplementing estrogen and progesterone levels of a biological organism, comprising:

mixing approximately 15% grapeseed oil with approximately 1.5% of a digestible emulsifier until dispersed to obtain a first mixture and heating said first mixture to approximately 80°

C. and then cooling said first mixture to approximately 60°

C.;

mixing approximately 6.06% distilled water and approximately 2% vegetable glycerin until dispersed to obtain a second mixture and heating said second mixture to approximately 70°

C. and then cooling said second mixture to approximately 60°

C.;

preparing a gelatinous medium by mixing approximately 15% cellulose gel with approximately 18.19% distilled water until dispersed and allowing said medium to gelatinize;

mixing approximately 681 grams of sarsaparilla, approximately 681 grams of licorice, approximately 1135 grams of black cohosh, approximately 454 grams of damiana, approximately 454 grams of dong quai and approximately 454 grams of burdock, to obtain a uniform dispersion of an active mixture in a powdered form;

mixing said first mixture and said second mixture to form a third mixture;

mixing said third mixture with approximately 5% of said active mixture and introducing approximately 6% wild yam, approximately 30% aloe vera juice, approximately 0.25% licorice phytosomes, and approximately 0.50% ginseng phytosomes to form a fourth mixture;

mixing said fourth mixture with said gelatinous medium to form said emulsified gel;

testing a pH of said emulsified gel;

adjusting said pH of said emulsified gel by adding an alkaline pH-modifying substance to accommodate approximately a 6.5 pH balance.

11. A process for preparing an emulsified gel comprising natural base steroidal hormones as defined in claim 10 further comprising introducing approximately 0.25% of methylparaben and approximately 0.25% of propylparaben into said second mixture.

12. A process for preparing an emulsified gel comprising natural base steroidal hormones as defined in claim 10 further comprising introducing approximately 454 grams of false unicorn, approximately 454 grams of squaw vine, approximately 454 grams of damiana, and approximately 454 grams of peony into said active mixture.

13. A process for preparing an emulsified gel comprising natural base steroidal hormones as defined in claim 10 wherein said alkaline pH-modifying substance comprises introducing a sufficient quantity of sodium bicarbonate to accommodate said 6.5 pH balance.

14. A process for preparing an emulsified gel comprising natural base steroidal hormones as defined in claim 10 wherein said digestible emulsifier comprises lecithin.

18. A process for preparing an active mixture of natural base steroidal hormones for supplementing estrogen and progesterone levels of a biological organism, comprising:

mixing approximately 1135 grams of black cohosh, approximately 681 grams of sarsaparilla, approximately 681 grams of licorice, approximately 454 grams of false unicorn, approximately 454 grams of dong quai, approximately 454 grams of wild yam, approximately 454 grams of squaw vine, and approximately 454 grams of damiana, to obtain a uniform dispersion of said active mixture in a powdered form; and

encapsulating approximately 575 milligrams of said active mixture into a gelatin capsule.

19. A process for preparing an active mixture of natural base steroidal hormones as defined in claim 18 further comprising replacing said wild yam with approximately 28 grams of blessed thistle.