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Complex combinatorial chemical libraries encoded with tags

  • US 5,565,324 A
  • Filed: 04/13/1994
  • Issued: 10/15/1996
  • Est. Priority Date: 10/01/1992
  • Status: Expired due to Term
First Claim
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1. A method for identifying a non-oligomeric compound which is heterocyclic, aromatic, alicyclic, aliphatic, or a combination thereof having a characteristic of interest, from a library of non-oligomeric compounds which comprises a plurality of discrete solid supports, each such support being characterized by having bound thereto a different non-oligomeric compound and multiple identifiers which encode the reaction stages and choices associated with the synthesis of the compound bound thereto, each such identifier being separately attached to the solid support and comprising a tag component, said method comprising:

  • (a) testing the library in an assay which identifies a solid support which has bound thereto a compound having the characteristic of interest so as to detect the presence in the library of any solid support having bound thereto a compound having the characteristic of interest;

    (b) treating the solid support so identified in step (a) so as to cause the tag components of each of the identifiers bound to such solid support to be released, wherein the release of the tag components from the solid support is effected photolyrically, oxidatively, hydrolyrically, thermolytically, or reductively;

    (c) determining the identity of each tag component so released, wherein determining the identity of each tag component is accomplished by gas chromatography, liquid chromatography, thin layer chromatography, electrophoresis, or mass spectrometry; and

    (d) determining said reaction stages and choices by which said non-oligomeric compound was synthesized, based on the identities of all such tag components so as to thereby identify the non-oligomeric compound having the characteristic of interest.

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