Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
First Claim
1. A method for making a polymeric composition capable of controlled release of a biologically active substance entrapped therein, the method comprising:
- mixing a biologically active substance with a solution of biodegradable, polymerizable macromer having a solubility of at least about 1 g/100 ml in aqueous solution, the macromer comprising at least one water soluble region, at least one degradable region which is hydrolyzable under in vivo conditions, and free radical polymerizable end groups having the capacity to form additional covalent bonds resulting in macromer interlinking, wherein the polymerizable end groups are separated from each other by at least one degradable region, in the presence of a free radical initiator, and polymerizing the macromer to entrap the biologically active substance within the resulting polymer.
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Abstract
Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
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Citations
38 Claims
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1. A method for making a polymeric composition capable of controlled release of a biologically active substance entrapped therein, the method comprising:
mixing a biologically active substance with a solution of biodegradable, polymerizable macromer having a solubility of at least about 1 g/100 ml in aqueous solution, the macromer comprising at least one water soluble region, at least one degradable region which is hydrolyzable under in vivo conditions, and free radical polymerizable end groups having the capacity to form additional covalent bonds resulting in macromer interlinking, wherein the polymerizable end groups are separated from each other by at least one degradable region, in the presence of a free radical initiator, and polymerizing the macromer to entrap the biologically active substance within the resulting polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A method for the controlled release of a biologically active substance, the method comprising:
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applying to a tissue surface or cells a biologically active substance, a free radical initiator and a biodegradable, polymerizable macromer, the macromer having a solubility of at least about 1 g/100 ml in aqueous solution, wherein the macromer comprises at least one water soluble region, at least one degradable region which is hydrolyzable under in vivo conditions, and free radical polymerizable end groups capable of forming covalent bonds resulting in macromer interlinking, and wherein the polymerizable end groups are separated from each other by at least one degradable region, permitting the macromer to polymerize on the tissue surface in the presence of the free radical initiator to entrap the biologically active substance within the polymerized macromer, and permitting the controlled release of the biologically active substance from the polymerized macromer. - View Dependent Claims (35, 36, 37, 38)
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Specification