Infection resistant medical devices

• US 5,567,495 A
• Filed: 07/11/1994
• Issued: 10/22/1996
• Est. Priority Date: 08/06/1993
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Sampath, Lester
• Primary Examiner(s): Seidleck, James J.
• Assistant Examiner(s): Williamson, Michael A.
• Application Number:
  US08/273,329
• Time in Patent Office: 834 Days
• Field of Search: 428/36.9, 428/36.91, 428/36.92, 604/265
• US Class Current: 428/36.9
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
• CPC Class Codes: Y10T 428/139 Open-ended, self-supporting conduit, cylinder, or tube-type article
• CPC Class Codes: Y10T 428/1393 Multilayer [continuous layer]
• CPC Class Codes: Y10T 428/1397 Single layer [continuous layer]

Abstract

The present invention provides for medical devices which are antiinfective as a result of antiinfective agents impregnated onto their surfaces and/or antiinfective activity incorporated into their access sites. It is based, at least in part, on the discovery that certain combinations of antimicrobial agents and solvents change the surface characteristics of polymeric medical devices, thereby facilitating the retention of antimicrobial agents. It is further based on the discovery that the incorporation of antiinfective polymeric inserts into the access site of a medical device provides substantially improved antiinfective activity.

Claims

1. An injection port comprising an antiinfective insert selected from the group consisting of an antiinfective disc and an antiinfective ring, wherein the antiinfective disc or antiifective ring is comprised of a ploymer which has been impregnated, at its surface, with an antiifective agent.

2. The injection port of claim 1, in which the antiinfective insert is an antiifective Dacron disc.

3. The injection port of claim 1, in which the antiifective insert in an antiifective polyurethane disc.

4. The injection port of claim 2, in which the antiinfective Dacron disc comprises chlorhexidine or a pharmaceutically acceptable salt thereof.

5. The injection port of claim 3, in which the antiinfective polyurethane disc comprises silver sulfadiazine.