Texaphyrins and uses thereof
First Claim
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1. A method of light-induced cleavage of a polymer of deoxyribonucleic acid, the method comprising:
- contacting the polymer with a photosensitive texaphyrin; and
exposing the photosensitive texaphyrin to light for a time sufficient to cleave the polymer.
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Abstract
A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.
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Citations
13 Claims
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1. A method of light-induced cleavage of a polymer of deoxyribonucleic acid, the method comprising:
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contacting the polymer with a photosensitive texaphyrin; and exposing the photosensitive texaphyrin to light for a time sufficient to cleave the polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification