Method and apparatus for quantitation of relevant blood parameters
First Claim
1. A method for quantitation of blood parameters, said blood parameters being coagulation time, sedimentation rate, hemocrit, fibrinogen concentration, platelet related coagulation activity, activity of the fibrinolytic system of the blood, rate of fibrinogen degeneration, amount of fibrin, and original figrinogen concentration, comprising the following steps:
- (a) providing a sample of plasma, serum or whole blood;
(b) entering the sample into a cuvette with an internal dimension less than 1 mm;
(c) illuminating the sample by a light source;
(d) measuring and recording the changes of light properties caused by the sample as a function of time to obtain a light signal versus time curve;
(e) calculating parameters of the recorded light signal/time curve; and
(f) interpreting the parameters as blood parameters.
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Abstract
A method for quantitation of blood parameters comprises the steps: provision of a sample of plasma, serum or blood, entering the sample into a cuvette with an internal dimension less than 1 mm, illuminating the sample by a light source, measuring and recording the changes of light properties caused by the sample as a function of time, calculating parameters of the recorded light signal/time curve such as slopes, extreme values, and the time distance between such extreme values, and interpreting the parameters as blood parameters. For the measurements, an apparatus is used comprising a cuvette (16, 17) with an internal dimension less than 1 mm, a light source (7, 9), means (8, 10) for measuring currently a light signal from the sample, means for recording the measured light signal values, and means for calculating parameters of the thereby defined light signal versus time graph.
66 Citations
19 Claims
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1. A method for quantitation of blood parameters, said blood parameters being coagulation time, sedimentation rate, hemocrit, fibrinogen concentration, platelet related coagulation activity, activity of the fibrinolytic system of the blood, rate of fibrinogen degeneration, amount of fibrin, and original figrinogen concentration, comprising the following steps:
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(a) providing a sample of plasma, serum or whole blood; (b) entering the sample into a cuvette with an internal dimension less than 1 mm; (c) illuminating the sample by a light source; (d) measuring and recording the changes of light properties caused by the sample as a function of time to obtain a light signal versus time curve; (e) calculating parameters of the recorded light signal/time curve; and (f) interpreting the parameters as blood parameters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19)
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16. An apparatus according to clam 15, further comprising more parallel acting capillary tubes.
Specification