Device for preparing a medicinal substance solution, suspension or emulsion

• US 5,569,191 A
• Filed: 07/19/1994
• Issued: 10/29/1996
• Est. Priority Date: 12/15/1992
• Status: Expired due to Fees

• Current Assignee: Gabriel Meyer
• Original Assignee: Gabriel Meyer
• Inventors: Meyer, Gabriel
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): KNIGHTS, LAIRD
• Application Number:
  US08/256,668
• Time in Patent Office: 833 Days
• Field of Search: 604/82-88, 604/92, 604/201-203, 604/205, 604/232, 604/411-413, 604/416, 215/DIG. 8, 222/82, 222/83, 222/83.5
• US Class Current: 604/82
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2031 having openings brought into alignment
• CPC Class Codes: A61J 1/2044 having slits
• CPC Class Codes: A61J 1/2051 having tap means, e.g. tap means activated by sliding
• CPC Class Codes: A61J 1/2086 for fluid filtration
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2039/042 Shrouds encircling the access needle preventing accidental needle-stick
• CPC Class Codes: A61M 5/2429 by telescoping of ampoules or carpules with the syringe body
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31515 Connection of piston with piston rod
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/50 having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile retractable needles or needle protectors with means for preventing re-use A61M5/321
• CPC Class Codes: A61M 5/5086 : for indicating if defective, used, tampered with or unsterile

Abstract

The invention concerns a device for the preparation of a medicinal solution from two components, one of which is in powder, lyophilisate or liquid form and the other a dilutant or a liquid solvent. These components respectively are charged in a rear container (11) and a front container (13), each of which has an opening closed off by a stopper-piston-dish, which is axially movable. Both these stopper-piston-dishes (19, 24) are connected by a conveyance shaft (15) adapted to ensure a rigid, tight and sterile coupling between the two stopper-piston-dishes (19, 24) when the device (10) is in a charging position, and to define a channel between both these containers (11, 13) when the device is in a position of use. The stopper-piston-dishes (19, 24) have a central zone provided with a slit (31, 33)m which is strongly compressed and closed in tight fashion when the device is in charging position, and which is open when one end of the conveyance shaft (15) is introduced therein, the device then being in the position of use. FIG. 1

Claims

1. Device for the preparation of at least one of a solution, a suspension and an emulsion from an active medicinal substance comprising:

a first component being in at least one of a powder form, a lyophilisate, a liquid, and a paste;

a second component being at least one of a dilutant and a liquid solvent;

a first container (11) for storing said first component, said first container being closed at a first end (17);

a second container (13) for storing said second component;

a first stopper piston dish (19) at a second end of said first container (11), said first stopper piston dish (19) being axially movable within said first container (11);

a second stopper piston dish (24) at a first end of said second container (13), said second stopper piston dish (24) being axially movable within said second container (13);

a conveyance shaft (15) connecting said first and second stopper piston dishes (19,

     24), said conveyance shaft (15) ensuring a rigid, tight, and sterile connection between said stopper piston dishes (19,

     24) when said device is in a charging position, and defining a tight and sterile channel of communication between said containers (11,

     13) when said device is in a use position, said use position being a position wherein said first stopper piston dish (19) of said first container (11) is at a higher level than said second stopper piston dish (24) of said second container (13);

at least one end of said conveyance shaft (15) being shaped in a plane substantially perpendicular to a longitudinal axis of said conveyance shaft;

a first slit (33) in a central zone of said first stopper piston dish (19), said first slit (33) being strongly compressed and tightly closed when said device is in said charging position, said first slit (33) being opened when a first end of said conveyance shaft (15) is introduced into said first slit (33) when said device is in said use position; and

a second slit (31) in a central zone of said second stopper piston dish (24), said second slit (31) being strongly compressed and tightly closed when said device is in said charging position, said second slit (31) being opened when a second end of said conveyance shaft (15) is introduced into said second slit (31) when said device is in said use position.

2. Device according to claim 1 comprising a sleeve (60) containing said second container (13) and at least partially containing said first container (11).

3. Device according to claim 2 comprising:

a cup (70) linked to said sleeve (60); and

a mechanism (71) linked to said sleeve (60) for application of multiple doses.

4. Device according to claim 2 wherein said sleeve (60) is integrally formed with said second container (13).

5. Device according to claim 2 comprising a ferrule for said sleeve (60), said ferrule comprising at least one of an ophthalmic drops applicator and a nasal vaporizer, integrally formed in said second container (13).

6. Device according to claim 2 comprising:

a first tubular element (42), within said sleeve (60), containing said first container (11); and

a second tubular element (40), within said sleeve (60), containing said second container (13), said first and second tubular elements being fitted one into another.

7. Device according to claim 6 comprising:

a plurality of catches (43) on said first tubular element (42);

at least two tongue shaped strips (44) on said second tubular element (40), being arranged to cooperate with said catches (43).

8. Device according to claim 1 comprising:

a first central groove (32) in said first stopper piston dish (19);

a second central groove (26) in said second stopper piston dish (24); and

means for tight and sterile coupling of said conveyance shaft (15) to said stopper piston dishes (19,

     24).

9. Device according to claim 1 comprising a plurality of stop abutments on said conveyance shaft (15), each said stopper piston dish (19, 24) has first surfaces, and said stop abutments support said first surfaces of said stopper piston dishes (19, 24) when said device is in said use position.

10. Device according to claim 1 wherein said stopper piston dishes (19, 24) support an inner side of said containers (11, 13) such that said containers (11, 13) is charged and handled independently, ensuring a tight and sterile closure of said containers (11, 13).

11. Device according to claim 1 wherein said conveyance shaft (15) ensures a tight, rigid and sterile connection of said stopper piston dishes (19, 24), said stopper piston dishes (19, 24) being respectively located in said first container (11) and said second container (13).

12. Device according to claim 1 wherein said second container (13) is adapted to receive a plurality of different ferrules and applicators for functioning in various therapeutical uses.