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Tricyclic derivatives

  • US 5,569,658 A
  • Filed: 07/19/1994
  • Issued: 10/29/1996
  • Est. Priority Date: 07/19/1993
  • Status: Expired due to Term
First Claim
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1. A tricyclic derivative of the formula Iwherein R1 and R2 together form a group of the formula --N═

  • CH--NH--, --N═

    N--NH--, --NH--N═

    CH--, --NH--CO--NH--, --NH--NH--CO--, --N═

    N--CH═

    CH--, --N═

    CH--N═

    CH--, --N═

    CH--CH═

    N--, or --N═

    CH--CO--NH-- (with in each case a nitrogen atom being located at the 6-position of the quinazoline ring) and the 5- or 6-membered ring so formed may optionally bear one or two substituents, any substituent on an available nitrogen atom being selected from (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, halogeno-(1-4C)alkyl, hydroxy-(1-4C)alkyl, (2-4C)alkanoyloxy-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, cyano-(1-4C)alkyl, amino-(i-4C)alkyl, (1-4C)alkylamino-(1-4C)alkyl and di-[(1-4C)alkyl]amino-(1-4C)alkyl, and any substituent on an available carbon atom being selected from halogeno, amino, hydroxy, carbamoyl, cyano, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkylsulphonyl, (1-4C)alkylamino, di-[(1-4C)alkyl]amino, (2-4C)alkanoyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, halogeno-(1-4C)alkyl, hydroxy-(1-4C)alkyl, (2-4C)alkanoyloxy-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, cyano-(1-4C)alkyl, amino-(1-4C)alkyl, (1-4C)alkylamino-(1-4C)alkyl and di-[(1-4C)alkyl]amino-(1-4C)alkyl; and

    m is the integer 1, 2 or 3 and each R3 is independently hydrogen, halogeno, trifluoromethyl, hydroxy, amino, nitro, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di-[(1-4C)alkyl]amino or (2-4C)alkanoylamino;

    or a pharmaceutically-acceptable salt thereof.

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