Altered fluid conductivity monitor

• US 5,570,026 A
• Filed: 05/31/1995
• Issued: 10/29/1996
• Est. Priority Date: 09/30/1992
• Status: Expired due to Term

• Current Assignee: Gambro Renal Products, Inc. (Baxter International Inc.)
• Original Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Inventors: Brugger, James M., Buffaloe, George W. IV, Ogawa, Francis T.
• Primary Examiner(s): Wieder, Kenneth A.
• Assistant Examiner(s): BROWN, GLENN WARNER
• Application Number:
  US08/455,349
• Time in Patent Office: 517 Days
• Field of Search: 324/439, 324/445, 324/450, 324/722, 210/96.1, 210/646, 436/150, 604/4, 604/30, 604/65, 604/246, 73/861.07, 73/861.08, 73/861.11, 73/861.16
• US Class Current: 324/445
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/3603 in the same direction
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/3658 Indicating the amount of purified blood recirculating in the fistula or shunt
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: G01F 1/7046 using electrical loaded particles as tracer, e.g. ions or electrons
• CPC Class Codes: G01F 1/708 Measuring the time taken to traverse a fixed distance
• CPC Class Codes: G01F 1/7088 using electrically charged particles as tracers

Abstract

A differential conductivity recirculation monitor quantitatively determines the degree of recirculation in a fistula by comparing the conductivity of blood entering the fistula to the conductivity of blood being withdrawn from the fistula. A discrete quantity of a high conductivity marker fluid is injected into the blood entering the fistula, altering the conductivity of the blood entering the fistula. The altered conductivity blood enters the fistula and, if recirculation is present, co-mingles with blood in the fistula, altering the conductivity of the blood in the fistula in proportion to the degree of recirculation. Blood withdrawn from the fistula has an altered conductivity related to the degree of recirculation. Quantitative values of the conductivity of the altered conductivity blood entering the fistula and the conductivity of the blood being withdrawn from the fistula are measured and a difference determined. The determined difference between the conductivities is used to determine a quantitative measurement of the degree of recirculation in the fistula.

Claims

1. A tubing set adapted for use with an apparatus for determining a degree of recirculation flow in a zone of a vessel into which a first fluid having a first electrical conductivity is being inserted and from which a second fluid having a second electrical conductivity is simultaneously being withdrawn, comprising:

a first conduit adapted to convey the first fluid with the first electrical conductivity before it is inserted into the zone of the vessel, said first conduit comprising a first conductivity cell with a first conductivity cell upstream connection, a first conductivity cell downstream connection, and two branches connecting the upstream connection to the downstream connection with a continuous path configuration from the upstream connection to the downstream connection through one of the two branches and returning to the upstream connection through the other one of the two branches, the upstream connection being connectable to a source of the first fluid; and

a second conduit adapted to convey the second fluid with the second electrical conductivity after it is withdrawn from the zone of the vessel, said second conduit comprising a second conductivity cell with a second conductivity cell upstream connection, a second conductivity cell downstream connection, and two branches connecting the upstream connection to the downstream connection with a continuous path configuration from the upstream connection to the downstream connection through one of the two branches and returning to the upstream connection through the other one of the two branches, the downstream connection being connectable to a destination of the second fluid.

2. A tubing set as defined in claim 1 wherein the first conductivity cell is adjacent to the second conductivity cell at a first junction in a generally parallel relationship.

3. A tubing set as defined in claim 2 wherein the first conductivity cell is adjacent to the second conductivity cell at a second junction in a generally angular relationship.

4. A tubing set as defined in claim 3 wherein:

each of the first and the second conductivity cells comprise tubing with cross-sectional configuration defined by a generally semicircular sidewall and an adjacent flat sidewall;

the flat sidewall of the first conductivity cell adjoins the flat sidewall of the second conductivity cell at the first junction; and

the flat sidewall of the first conductivity cell adjoins the flat sidewall of the second conductivity cell at the second junction.

5. A tubing set as defined in claim 1 wherein:

the zone of the vessel is a surgically formed arteriovenous fistula;

the first conduit is an outlet line of a medical device for blood processing; and

the second conduit is an inlet line of the medical device for blood processing.

6. A tubing set as defined in claim 5 wherein the medical device for blood processing is a hemodialysis device.

7. A tubing set as defined in claim 1 further comprising:

a hypodermic needle access site in the first conduit in fluid communication with the first conductivity cell upstream connection.