Pilocarpine-containing chewing gum that stimulates salivation

• US 5,571,528 A
• Filed: 06/28/1995
• Issued: 11/05/1996
• Est. Priority Date: 06/30/1994
• Status: Expired due to Term

• Current Assignee: Amazonbio, Ltd.
• Original Assignee: Hong-Ryeol Ryu, Sung-Woo Lee
• Inventors: Lee, Sung-Woo, Ryu, Hong-Ryeol
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US08/496,216
• Time in Patent Office: 496 Days
• Field of Search: 424/439, 424/440, 424/441, 514/772.3
• US Class Current: 424/440
• CPC Class Codes: A61K 31/4178 not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• CPC Class Codes: A61K 9/0058 Chewing gums non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00

Abstract

The present invention is a pilocarpine containing chewing gum for stimulating salivation. The invention contains 0.13-0.20 weight % of pilocarpine as well as normal gum base that includes sweetening agents and flavors. It can improve oral hygiene by stimulating parasympathetic innervation in salivary glands with pilocarpine solubilized in the oral cavity.

Claims

1. A pilocarpine-containing chewing gum comprising:

4˜

5 mg of pilocarpine and 2.5˜

3 g of a base material, and,

said base material comprising;

a mixture of chicle, latex rubber (major component of a normal gum base), a hydrogenated esterified rubber base, paraffin wax, stearic acid, and xylitol(glycoalcohol).

2. A pilocarpine-containing chewing gum comprising:

0.13˜

0.20 weight % of pilocarpine and a gum base, and,

said gum base comprising;

a mixture of 30 weight % of a styrene-butadiene copolymer, 3 weight % of a hydrogenated esterified rubber base, 5 weight % of paraffin wax, 2 weight % of stearic acid and 59˜

60 weight % of glycoalcohol.