Iontophoretic drug delivery
First Claim
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1. An iontophoretic electrode for delivery of as an ionic drug having a positive charge, comprising:
- a reservoir containing a positively charged ionic drug compounded with a negatively charged counterion, said reservoir comprised of a hydrophilic polymer, which when hydrated is permeable to said ionic drug, and which is substantially free of competing cations;
an electrically conductive member comprising a material that is readily oxidizable to form a positively charged ionic species differing from said positively charged ionic drug, when said conductive member is in contact with said reservoir and a positive voltage is applied to said conductive reservoir.
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Abstract
Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
93 Citations
23 Claims
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1. An iontophoretic electrode for delivery of as an ionic drug having a positive charge, comprising:
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a reservoir containing a positively charged ionic drug compounded with a negatively charged counterion, said reservoir comprised of a hydrophilic polymer, which when hydrated is permeable to said ionic drug, and which is substantially free of competing cations; an electrically conductive member comprising a material that is readily oxidizable to form a positively charged ionic species differing from said positively charged ionic drug, when said conductive member is in contact with said reservoir and a positive voltage is applied to said conductive reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 22, 23)
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14. An iontophoresis electrode for delivery of an ionic drug having a negative charge, comprising:
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a reservoir containing a negatively charged ionic drug compounded with a positively charged counterion, and through which said ionic drug is permeable; and an electrically conductive member, applied to said reservoir, said electrically conductive member comprising a material that is readily reducible to form a negatively charged ionic species differing from said negatively charged ionic drug, when said conductive member is in contact with said reservoir and a negative voltage is applied to said conductive reservoir. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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Specification