Medicinal bone mineral products

• US 5,573,771 A
• Filed: 02/21/1995
• Issued: 11/12/1996
• Est. Priority Date: 08/19/1988
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: Osteomedical Limited
• Inventors: Pfirrmann, Rolf W., Geistlich, Peter
• Primary Examiner(s): Kishore, Gollamudi S.
• Application Number:
  US08/391,247
• Time in Patent Office: 630 Days
• Field of Search: 424/422, 424/423, 424/426, 424/484, 424/549, 424/489-492, 424/494, 623/16, 623/66, 530/356, 514/2, 514/8, 514/21
• US Class Current: 424/422
• CPC Class Codes: A61L 2300/204 with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/3687 characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 5/02 Dextran; Derivatives thereof
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: Y10S 623/919 Bone
• CPC Class Codes: Y10S 623/923 Bone

Abstract

The invention provides a purified particulate bone mineral product for use in medicine, the particles of said mineral being substantially free from all endogenous organic material and having at least at the surface thereof resorbable, physiologically compatible, natural or synthetic macromolecular material. In particular the invention provides a bone mineral impregnated with a gel-forming protein or polysaccharide such as gelatin to provide a surprising increase in strength and a product comprising bone mineral in a matrix of collagen-fibres and a gel-forming protein. Such products are intended as remodeling implants or prosthetic bone replacement.

Claims

1. A particulate bone mineral product for use in medicine comprising porous bone mineral particles derived from natural bone having a crystal structure of natural bone and substantially free from all endogenous organic material, the particles having an average diameter in the range of 0.1 to 10 mm, and having at least at the surface thereof resorbable, physiologically compatible, collagen fibers in an amount which increases the strength of the bone mineral particles wherein the weight ratio of said collagen fibers to said porous bone mineral particles is at least 1:

20'"'"'.

2. A product as claimed in claim 1 in which the bone mineral is prepared by completely de-greasing particulate bone and treating it with ammonia or an amine to degrade residual protein followed by extensive water washing.

3. A product as claimed in claim 1 which further comprises at least one absorbed pharmaceutically active substance.

4. A product as claimed in claim 3 in which said pharmaceutically active substance is taurolidine or taurultam.

5. A product as claimed in claim 3 in which said physiologically active substance is capable of assisting bone regeneration and is selected from morphogenic growth factors, angiogenic growth factors, transforming growth factors, ossein, and osteopoietin.

6. A method of treatment of a human or animal subject wherein a bone mineral product as claimed in claim 1 is used as a remodelling implant or prosthesis.

7. A product as claimed in claim 1 in which the weight ratio of the collagen fibers to the bone material is in the range of 1:

20 to 3;

20.

8. A product as claimed in claim 1, further comprising gelatin in a gel phase, wherein said collagen fibers are present in said gel phase, and wherein said gel phase comprises 2 to 8% by weight of the bone material.