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Adrenergic receptor as a proto-oncogene

  • US 5,573,908 A
  • Filed: 12/20/1993
  • Issued: 11/12/1996
  • Est. Priority Date: 12/16/1991
  • Status: Expired due to Term
First Claim
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1. An in vitro assay procedure, comprising:

  • contacting a test compound to a recombinant cell, the recombinant cell comprising a mammalian host cell containing a heterologous DNA molecule, the heterologous DNA molecule comprising vector DNA and DNA which encodes a mammalian α

    1 -adrenergic receptor, wherein said mammalian α

    1 -adrenergic receptor is expressed in said host cell, and wherein said recombinant cell undergoes proliferation in response to activation of said mammalian α

    1 -adrenergic receptor; and

    detecting whether or not said test compound inhibits the proliferation of said recombinant cell.

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