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Oligonucleotide synthesis with substituted aryl carboxylic acids as activators

  • US 5,574,146 A
  • Filed: 08/30/1994
  • Issued: 11/12/1996
  • Est. Priority Date: 08/30/1994
  • Status: Expired due to Term
First Claim
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1. A composition comprising a secondary amine and an in situ generated compound of formula Ia or Ib:

  • ##STR7## wherein;

    B is a purine or pyrimidine base;

    R is a hydroxyl-protecting group;

    R'"'"' is a substituted aryl;

    R" is selected from the group consisting of lower alkyl, lower alkoxy, NCCH2 CH2 O--, NCCH2 CH2 MeO--, NCCH2 CMe2 O--, Cl3 CCH2 O--, Cl3 CCMe2 O--, C6 H5 SO2 CH2 CH2 O--, MeSO2 CH2 CH2 O--, and NO2 C6 H4 CH2 CH2 O--.

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