Device for determining an opening pressure in the lungs

• US 5,575,283 A
• Filed: 02/13/1995
• Issued: 11/19/1996
• Est. Priority Date: 02/14/1994
• Status: Expired due to Term

• Current Assignee: Maquet Critical Care AB (Getinge AB)
• Original Assignee: Siemens-Elema AB (Siemens AG)
• Inventors: Sjoestrand, Ulf
• Primary Examiner(s): Millin, V.
• Assistant Examiner(s): Deane, Jr., William J.
• Application Number:
  US08/387,186
• Time in Patent Office: 645 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.22, 128/204.23, 128/204.26, 128/205.24
• US Class Current: 128/204.23
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit

Abstract

Most alveoli could collapse in different illnesses and injuries to a lung. A relatively high positive pressure, which could in itself damage the lung or impede its healing, is required to open the alveoli. A positive pressure is often applied at the end of the expiratory phase in order to keep the alveoli open throughout entire respiratory cycles. A ventilator is disclosed wherein an opening pressure for the lung can be determined from measurement values for the pressure and the volume of air supplied to the lung. The ventilator registers the measurement values and determines the opening pressure from the relationship between measurement values for pressure and for volume. The determined opening pressure can then be used by a physician for setting an appropriate end expiratory pressure (PEEP) for the respiratory phase or be used by a control unit in the ventilator for automatic setting of an appropriate end expiratory pressure.

Claims

1. A ventilator comprising:

respiratory-assist means, connectable to a patient, for assisting respiration of said patient by supplying a regulated flow of air to the lungs of said patient, said regulated flow of air having a volume and producing air pressure in the lungs;

pressure gauge means for measuring said air pressure in the lungs;

volume-determining means for measuring the volume of air supplied to the lungs in said regulated flow of air;

registration means, connected to said pressure gauge means and to said volume-determining means, for registering said air pressure and said volume over a time period, said air pressure and said volume having a relationship in said time period;

calculator means, supplied from said registration means with said air pressure and said volume registered over said time period, for calculating from said relationship an opening pressure which will inflate at least some alveoli in the lungs; and

means for controlling said respiration-assist means to regulate said flow of air dependent on said opening pressure.

2. A ventilator as claimed in claim 1 further comprising:

display means, connected to said calculating means, for displaying said opening pressure.

3. A ventilator as claimed in claim 1 wherein said respiration-assist means includes an expiration line connectable to said patient, an expiratory valve disposed in said expiration line, and control means, connected to said calculation means and to said expiratory valve, for operating said expiratory valve dependent on said opening pressure for maintaining a positive end expiratory pressure, greater than ambient pressure, in the lungs at an end of an expiratory phase of said patient.

4. A ventilator as claimed in claim 3 wherein said control means comprises means for setting a lowest end pressure in the lungs as a selected percent of said opening pressure.

5. A ventilator as claimed in claim 4 wherein said control means comprises means for setting said lowest end pressure in the lungs at a pressure in a range of from 60 to 100% of said opening pressure.

6. A ventilator as claimed in claim 3 wherein said respiration-assist means comprises means for supplying a predetermined volume of air to the lungs during an inspiratory phase of each respiratory cycle of said patient, wherein said registration means comprises means for registering said air pressure in the lungs at the end of said inspiratory phase of each respiratory cycle, wherein said calculating means comprises means for calculating a relative increase in pressure arising in the lungs when said predetermined volume of air is supplied to the lungs and for determining, over a selected number of respiratory cycles, which comprise said time period, whether said relative pressure increase is declining, increasing or is unchanged.

7. A ventilator as claimed in claim 6 wherein said control means comprises means for maintaining said relative increase constant by controlling said respiratory-assist means to vary said positive and expiratory pressure.

8. A ventilator as claimed in claim 1 further comprising means for automatically activating said registration means and said calculator means at specific intervals.

9. A ventilator as claimed in claim 1 wherein said calculating means comprises means for setting said opening pressure at a pressure at which the volume registered by the said registration means exceeds a threshold value.

10. A ventilator as claimed in claim 9 wherein said respiration-assist means includes an expiratory line endotracheally connectable to said patient, an expiratory valve disposed in said expiratory line, and control means for automatically operating said expiratory valve dependent on said opening pressure for maintaining a positive end expiratory pressure, greater than ambient pressure, in the lungs at the end of an expiratory phase of said patient, including setting a lowest end pressure in the lungs as a selected percent of said opening pressure.

11. A ventilator as claimed in claim 9 wherein said respiration-assist means comprises means for supplying a predetermined volume of air to the lungs during said inspiratory phase of each respiratory cycle, wherein said calculation means comprises means for calculating a relative increase in pressure arising in the lungs when said predetermined volume of air is supplied to the lungs and for calculating, over a selected number of respiratory cycles, comprising said time period, whether said relative increase is declining, increasing or is unchanged, and for maintaining said pressure increase constant by controlling said respiration-assist means to vary the positive and expiratory pressure.

12. A ventilator as claimed in claim 1 wherein said calculating means comprises means for setting said opening pressure at a pressure at which a predetermined increase in pressure causes an increase in said volume which exceeds a predetermined volume.

13. A ventilator as claimed in claim 12 wherein said respiration-assist means includes an expiratory line endotracheally connectable to said patient, an expiratory valve disposed in said expiratory line, and control means for automatically operating said expiratory valve dependent on said opening pressure for maintaining a positive end expiratory pressure, greater than ambient pressure, in the lungs at the end of an expiratory phase of said patient, including setting a lowest end pressure in the lungs as a selected percent of said opening pressure.

14. A ventilator as claimed in claim 12 wherein said respiration-assist means comprises means for supplying a predetermined volume of air to the lungs during said inspiratory phase of each respiratory cycle, wherein said calculation means comprises means for calculating a relative increase in pressure arising in the lungs when said predetermined volume of air is supplied to the lungs and for calculating, over a selected number of respiratory cycles, comprising said time period, whether said relative increase is declining, increasing or is unchanged, and for maintaining said pressure increase constant by controlling said respiration-assist means to vary the positive and expiratory pressure.

15. A ventilator as claimed in claim 1 wherein said calculating means comprises means for formulating a curve of air pressure values versus volume values which, within a predetermined interval of said inspiratory phase, is optimally fitted to the air pressure and volume registered by said registration means, and for setting said opening pressure at a pressure at which the fitted curve assumes a predetermined volume value.

16. A ventilator as claimed in claim 15 wherein said calculating means comprises means for setting said opening pressure at a pressure at which said fitted curve assumes a volume value of zero.

17. A ventilator as claimed in claim 15 wherein said calculating means comprises means for fitting said curve to said air pressure and volume registered by said registration means according to the least squares method.

18. A ventilator as claimed in claim 15 wherein said calculating means comprises means for fitting said curve to said air pressure and said volume registered by said registration by fitting a linear curve to said air pressure and said volume registered by said registration means within said predetermined interval of the respiratory phase.

19. A ventilator as claimed in claim 15 wherein said calculating means comprises means for fitting said curve to said air pressure and said volume registered by said registration by fitting a non-linear curve to said air pressure and said volume registered by said registration means within said predetermined interval of the respiratory phase.

20. A ventilator as claimed in claim 15 wherein said calculating means comprises means for formulating said curve within an interval of said respiratory phase between a minimum volume and a maximum volume registered by said registration means.

21. A ventilator as claimed in claim 15 wherein said respiration-assist means includes an expiratory line endotracheally connectable to said patient, an expiratory valve disposed in said expiratory line, and control means for automatically operating said expiratory valve dependent on said opening pressure for maintaining a positive end expiratory pressure, greater than ambient pressure, in the lungs at the end of an expiratory phase of said patient, including setting a lowest end pressure in the lungs as a selected percent of said opening pressure.

22. A ventilator as claimed in claim 15 wherein said respiration-assist means comprises means for supplying a predetermined volume of air to the lungs during said inspiratory phase of each respiratory cycle, wherein said calculation means comprises means for calculating a relative increase in pressure arising in the lungs when said predetermined volume of air is supplied to the lungs and for calculating, over a selected number of respiratory cycles, comprising said time period, whether said relative increase is declining, increasing or is unchanged, and for maintaining said pressure increase constant by controlling said respiration-assist means to vary the positive and expiratory pressure.