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Marker and an assay for detection and monitoring of human immunodeficiency virus latency and activation

  • US 5,576,176 A
  • Filed: 03/03/1994
  • Issued: 11/19/1996
  • Est. Priority Date: 03/03/1994
  • Status: Expired due to Fees
First Claim
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1. A method for assessment of HIV transcriptional activity and disease progression wherein nonprocessive transcription indicates viral latency and processive transcription indicates active viral gene expression, wherein the method comprises determining a ratio of total RNA transcripts to processive RNA transcripts in infected cells of HIV positive subjects, and correlating a change in said ratio with disease progression wherein total RNA transcripts plus long transcripts and wherein short transcripts consist of SEQ ID NO:

  • 1 and long transcripts comprise SEQ ID NO;

    1 as a leader sequence of the full length viral mRNA wherein the level of said ratio indicates nonprocessive or processive transcription and the change in said ratio indicates a transition from latency to activation and correlates with disease progression.

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