Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
First Claim
Patent Images
1. An oligonucleotide represented by SEQ ID NO:
- 1 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
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Abstract
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis.
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Citations
30 Claims
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1. An oligonucleotide represented by SEQ ID NO:
- 1 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (3, 21)
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2. An oligonucleotide represented by SEQ ID NO:
- 1 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (4, 22)
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5. An oligonucleotide represented by SEQ ID NO:
- 2 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (7, 23)
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6. An oligonucleotide represented by SEQ ID NO:
- 2 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (8, 24)
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9. An oligonucleotide represented by SEQ ID NO:
- 3 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (11, 25)
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10. An oligonucleotide represented by SEQ ID NO:
- 3 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (12, 26)
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13. An oligonucleotide represented by SEQ ID NO:
- 4 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (15, 27)
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14. An oligonucleotide represented by SEQ ID NO:
- 4 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (16, 28)
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17. An oligonucleotide represented by SEQ ID NO:
- 5 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (19, 29)
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18. An oligonucleotide represented by SEQ ID NO:
- 5 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (20, 30)
Specification