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Compounds having effects on serotonin-related systems

  • US 5,576,321 A
  • Filed: 06/06/1995
  • Issued: 11/19/1996
  • Est. Priority Date: 01/17/1995
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula ##STR46## wherein r is 0-4;

  • s is 0-1;

    D is a residue which combines with the carbon atoms to which it is attached to complete a pyrrolyl group;

    wherein X is hydrogen, phenyl, hydroxy or methoxy;

    provided that X is hydrogen or phenyl when r is 0;

    R is
    
    
    space="preserve" listing-type="equation">--NH--R.sup.1 IIR1 is piperidinyl, piperazino, morpholino or pyrrolyl, substituted with 0-1 phenyl or benzyl group or 0-4 C1 -C3 alkyl, C1 -C3 alkoxy or halo groups;

    which phenyl or benzyl group is substituted with 0-2 C1 -C3 alkyl, halo, trifluoromethyl or C1 -C3 alkoxy groups;

    or R1 is ##STR47## n and m are independently 4-5, and the group of Formula VI may be substituted with 0-1 oxo group and 0-2 C1 -C3 alkyl, C1 -C3 alkoxy or halo groups;

    or R1 is C1 -C4 alkyl, substituted with pyrrolyl, furyl, thienyl, morpholinyl, piperidinyl, tetrahydropyrrolyl, piperazinyl, tetrahydrofuryl, benzazepinyl, dibenzazepinyl or quinotinyl, substituted with 0-4 C1 -C3 alkyl, C1 -C3 alkoxy or halo groups;

    or a pharmaceutically acceptable salt thereof.

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