Means for increasing sensitivity in non-linear ultrasound imaging systems

• US 5,577,505 A
• Filed: 02/06/1996
• Issued: 11/26/1996
• Est. Priority Date: 02/06/1996
• Status: Expired due to Term

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Hewlett-Packard Company (HP Inc.)
• Inventors: Poland, Mckee D., Rafter, Patrick G., Brock-Fisher, George A.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US08/597,697
• Time in Patent Office: 294 Days
• Field of Search: 128/660.01, 128/662.02, 424/9.1, 424/9.32, 424/9.321
• US Class Current: 600/458
• CPC Class Codes: G01S 15/895 characterised by the transmitted frequency spectrum
• CPC Class Codes: G01S 7/52033 Gain control of receivers for seismic signals G01V1/245
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target
• CPC Class Codes: G01S 7/52039 exploiting the non-linear response of a contrast enhancer, e.g. a contrast agent diagnostic techniques involving the use of contrast agents A61B8/481

Abstract

An image with increased sensitivity to non-linear responses, particularly second harmonic responses, can be achieved by measuring the ultrasound response under multiple excitation levels. The responses gathered from the multiple excitation levels are gain corrected in an amount corresponding to the difference in excitation levels, then subtracted. Because of this subtraction, most of the linear response will be removed, and what remains corresponds to the non-linear response.

Claims

1. A method for measuring a non-linear response of tissue and bubbles comprising the steps of:

exciting and measuring a first response at a first power setting;

exciting and measuring a second response at a second power setting, wherein the second power setting is different than the first power setting;

scaling the first response for the second power setting to produce a projected response; and

subtracting the projected response from the second response to determine the non-linear response.

2. A method, as defined in claim 1, wherein the first and second power settings are voltage levels.

3. A method, as defined in claim 2, wherein the first power setting is half the second power setting.

4. A method, as defined in claim 2, wherein the first power setting is half the second power setting.

5. A method, as defined in claim 1, wherein the step of exciting and measuring a first response includes the step of selecting the first power setting by reducing the aperture such that some of the transducer assembly is active.

6. A method, as defined in claim 5, wherein the step of reducing the aperture includes symmetrically firing a subset of elements of the transducer assembly.

7. A method, as defined in claim 5, wherein:

the step of reducing the aperture further includes,

partitioning the transducer assembly into two groups using a synthetic aperture, and

firing a line from each of the two groups;

the step of exciting and measuring the second response further includes, firing the whole aperture in the same line, and

the step of scaling includes grouping the response from the two groups and comparing the grouped response with the second response to determine the non-linearity of the bubbles and the tissue.

8. A method for measuring a non-linear response of tissue and bubbles comprising the steps of:

exciting and measuring responses at each one of a group of power levels, wherein the group has at least two different power levels;

scaling each response according to its power setting to produce a projected response; and

subtracting linear combinations of the projected responses to determine the non-linear response.

9. A method, as defined in claim 8, wherein the different power levels of the power group are voltage levels.

10. A method, as defined in claim 8, wherein the step of exciting and measuring each response includes the step of selecting one of the power group by reducing the aperture such that some of the transducer assembly is active.

11. A method, as defined in claim 10, wherein the step of reducing the aperture includes symmetrically firing a subset of elements of the transducer assembly.

12. A method, as defined in claim 10, wherein:

the step of reducing the aperture further includes,

partitioning the transducer assembly into two groups using a synthetic aperture, and

firing a line from each of the two groups;

the step of exciting and measuring the second response further includes, firing the whole aperture in the same line, and

the step of scaling includes grouping the response from the two groups and comparing the grouped response with the second response to determine the non-linearity of the bubbles and the tissue.