Automated blood analysis system with an integral centrifuge

• US 5,578,269 A
• Filed: 12/08/1993
• Issued: 11/26/1996
• Est. Priority Date: 06/11/1993
• Status: Expired due to Term

• Current Assignee: Ortho Diagnostic Systems, Inc. (The Carlyle Group LP (Corporate Private Equity))
• Original Assignee: Ortho Diagnostic Systems, Inc. (The Carlyle Group LP (Corporate Private Equity))
• Inventors: Frischknecht, Marcel, Kuster, Martin, Batliner, Gregor, Puchegger, Karl, Imfeld, Walter, Yaremko, Mykola, Chachowski, Rosemary, Kunz, Hansjoerg, Flueler, Linus, Forster, Marco, Gretener, Beat, Gander, Martin
• Primary Examiner(s): Le, Long V.
• Application Number:
  US08/163,997
• Time in Patent Office: 1,084 Days
• Field of Search: 422/63-67, 422/68.1, 422/72, 422/73, 422/100, 422/104, 436/43, 436/45, 436/47, 436/48, 436/49, 436/174, 436/177, 436/180, 436/805, 436/807, 356/39, 356/40, 210/361, 210/362, 210/380.1, 210/380.3
• US Class Current: 422/64
• CPC Class Codes: G01N 2035/00495 Centrifuges
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/0449 using centrifugal transport of liquid
• CPC Class Codes: G01N 2035/0455 Coaxial carousels
• CPC Class Codes: G01N 2035/0465 Loading or unloading the conveyor
• CPC Class Codes: G01N 2035/1025 Fluid level sensing
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A blood analysis system or instrument, generally, including an incubator station, a sample and reagent holding station, a pipette assembly, a centrifuge, an analysis station, and a transport assembly. Generally, the incubation station holds containers while reagents and fluids are being dispensed in those containers, and, if desired, for incubating the containers. The sample and reagent holding station holds samples and a plurality of reagents, and the pipette assembly transfers fluids from that sample and reagent holding station to containers in the incubation station. The centrifuge is provided for centrifuging the container, and the analysis station is provided to analyze the containers optically to identify reactions therein. The transport assembly carries the containers between the incubator station, the centrifuge, and the analysis station. Preferably, the pipette assembly is automatically operated to draw fluids and preselected reagents from the sample and reagent holding station, and to dispense fluids into the containers held in the incubation station to produce predetermined solutions therein. Also, the transport subassembly is automatically operated to carry containers from the incubator station to the centrifuge after the predetermined solutions have been produced in the containers, and then to carry the containers from the centrifuge to the analysis station.

Claims

1. An automated analysis system for analyzing aqueous solutions, comprising:

an incubator station for holding and incubating a plurality of containers;

a sample station for holding a plurality of samples of aqueous solutions;

a reagent station for holding a plurality of reagents;

a pipette assembly for drawing aqueous solutions from the sample station, for drawing reagents from the reagent stations and for dispensing aqueous solutions and reagents into the containers at the incubator station;

a centrifuge for centrifuging the containers;

an analysis station for analyzing the containers to identify reactions therein; and

a transport assembly for transporting the containers between the incubator station, the centrifuge, and the analysis station;

wherein the centrifuge includes;

a rotor including a rotatable body and a plurality of arms connected to and radially extending outward from the body;

motor means connected to the rotor to rotate the rotor; and

a plurality of container mounting brackets connected to the arms of the rotor, and forming container receiving means to hold the container on the rotor for rotary movement therewith and for pivotal movement relative to the arms of the rotor, wherein each of the mounting brackets is mounted on a respective one of the rotor arms and includes

i) a left side member,

ii) a right side member,

iii) means pivotally mounting the left and right side members on opposite lateral sides of the respective one of the rotor arms, and

iv) means connecting the left and right side members together for pivotal movement together, wherein said container receiving means are formed by adjacent left and right side members of each pair of adjacent mounting brackets.

2. An analysis system according to claim 1, wherein:

said means pivotally mounting the left and right side members on the respective one of the rotor arm includes a mounting rod positioned on said respective one of the rotor arms;

the mounting rod includes first and second ends laterally extending past the said one rotor arm;

the left side member is mounted on the first end of the mounting rod; and

the right side member is mounted on the second end of the mounting rod.

3. An analysis system according to claim 2, wherein said means pivotally mounting the left and right side members on said one rotor arm further includes a retaining member releasably connected to said respective one of rotor arms and extending over the mounting rod to hold the mounting rod on said rotor arm.