Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
First Claim
1. A mucosal adhesive dosage unit adapted to use for treatment of oral cavity infection selected from a) the forms consisting of a dosage unit wherein mucoadhesive polymer layer having intermixed pharmaceuticals is adhered to a protective backing layer, and b) a tablet comprising a mucosal adhesive polymer mixture having intermixed pharmaceuticals;
- said mucosal adhesive dosage unit adhering to the oral mucosal tissue for at least about 12 hours,said mucosal adhesive dosage unit having a therapeutic dosage amount of one or more antimicrobial agents and one or more anti-inflammatory agents,said dosage unit releasing the antimicrobial agent and anti-inflammatory agent at a substantially constant rate for at least 12 hours to treat infection in the oral mucosa.
1 Assignment
0 Petitions
Accused Products
Abstract
Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal agents and anti-inflammatory agents, optionally also a local anesthetic. The dosage units yield a gradual and relatively constant release of the pharmaceuticals over at least a 12-hour period.
147 Citations
8 Claims
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1. A mucosal adhesive dosage unit adapted to use for treatment of oral cavity infection selected from a) the forms consisting of a dosage unit wherein mucoadhesive polymer layer having intermixed pharmaceuticals is adhered to a protective backing layer, and b) a tablet comprising a mucosal adhesive polymer mixture having intermixed pharmaceuticals;
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said mucosal adhesive dosage unit adhering to the oral mucosal tissue for at least about 12 hours, said mucosal adhesive dosage unit having a therapeutic dosage amount of one or more antimicrobial agents and one or more anti-inflammatory agents, said dosage unit releasing the antimicrobial agent and anti-inflammatory agent at a substantially constant rate for at least 12 hours to treat infection in the oral mucosa. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification