Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom

• US 5,578,662 A
• Filed: 06/07/1995
• Issued: 11/26/1996
• Est. Priority Date: 07/22/1994
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: United States Surgical Corporation (Medtronic Plc)
• Inventors: Jiang, Ying, Gruskin, Elliott A., Bennett, Steven L., Connolly, Kevin M.
• Primary Examiner(s): BUTTNER, DAVID J
• Application Number:
  US08/477,098
• Time in Patent Office: 538 Days
• Field of Search: 525/408, 525/409, 525/411, 525/413, 525/415, 528/73, 528/76, 524/54, 424/426, 424/78.06, 604/304
• US Class Current: 524/54
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/58 for osteosynthesis, e.g. bone plates, screws , setting implements or the like A61B17/14, A61B17/16 take precedence
• CPC Class Codes: A61L 17/12 Homopolymers or copolymers of glycolic acid or lactic acid
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08G 63/06 derived from hydroxycarboxylic acids
• CPC Class Codes: C08G 63/912 derived from hydroxycarboxylic acids
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

Claims

1. A bioabsorbable composition comprising a branched copolymer containing a major amount of alkylene oxide units and a minor amount of units derived from a bioabsorbable monomer, said copolymer being endcapped with at least one lysine isocyanate group.

2. The composition of claim 1 wherein the alkylene oxide units are selected from the group consisting of ethylene oxide, propylene oxide and combinations thereof.

3. The composition of claim 1 wherein the bioabsorbable monomer is selected from the group consisting of glycolic acid, glycolide, lactic acid, lactide, p-dioxanone, trimethylene carbonate, trimethylene dimethylene carbonate, dioxepanone, alkylene oxalates, epsilon-caprolactone, and combinations thereof.

4. The composition of claim 1 wherein the units derived from a bioabsorbable monomer represent about 20 weight percent of the copolymer.

5. The composition of claim 1 wherein the units derived from a bioabsorbable monomer represent about 5 weight percent of the copolymer.

6. The composition of claim 1 wherein the copolymer is linear or branched.

7. The composition of claim 1 wherein the copolymer is a random, block or graft copolymer.

8. The composition of claim 1 wherein the copolymer possesses a molecular weight of less than about 6,000.

9. The composition of claim 1 wherein the isocyanate group is derived frown diisocyanatolysine ethyl ester.

10. The composition of claim 1 wherein the bioabsorbable monomer is selected from the group consisting of glycolic acid, glycolide, lactic acid and lactide.

11. The composition of claim 1 further comprising a filler.

12. The composition of claim 1 further comprising a charge inducing agent.

13. The composition of claim 1 further comprising a therapeutic agent.

14. The composition of claim 13 wherein the therapeutic agent is cross-linked dextran.

15. A method for promoting wound healing which comprises contacting a wound site with the bioabsorbable composition of claim 13.

16. A bioabsorbable composition comprising a branched copolymer containing a major amount of alkylene oxide units and a minor amount of units derived from a bioabsorbable monomer selected from the group consisting of glycolic acid, glycolide, lactic acid, lactide, p-dioxanone, trimethylene carbonate, trimethylene dimethylene carbonate, dioxepanone alkylene oxalates, epsilon-caprolactone, and combinations thereof, said copolymer being endcapped with at least one isocyanate group derived from diisocyanatolysine ethyl ester.