Macromolecular microparticles and methods of production
First Claim
Patent Images
1. A method for making microparticles having uniform size comprising the steps of:
- a) combining a solution containing a macromolecule with a solution containing both polyvinylpyrrolidone and polyethylene glycol to produce a reaction solution;
b) incubating the reaction solution at a predetermined temperature greater than room temperature for a sufficient amount of time to form microparticles; and
c) separating the microparticles from the reaction solution.
3 Assignments
0 Petitions
Accused Products
Abstract
A macromolecular microparticle composition formed by dehydrating an aqueous macromolecule solution and crosslinking the dehydrated macromolecules with a crosslinking agent while in a liquid phase or with heat. Preferably, the dehydrating agent is a polymer mixture of polyvinylpyrrolidone and polyethylene glycol, the crosslinking reagent is glutaraldehyde, and the macromolecule is a protein, most preferably an immunoglobulin. Methods of use for research, diagnostics and therapeutics are also provided.
-
Citations
18 Claims
-
1. A method for making microparticles having uniform size comprising the steps of:
-
a) combining a solution containing a macromolecule with a solution containing both polyvinylpyrrolidone and polyethylene glycol to produce a reaction solution; b) incubating the reaction solution at a predetermined temperature greater than room temperature for a sufficient amount of time to form microparticles; and c) separating the microparticles from the reaction solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. Microparticles prepared by the method of
a) combining a solution containing a macromolecule with a solution containing both polyvinylpyrrolidone and polyethylene glycol to produce a reaction solution; -
b) incubating the reaction solution at a predetermined temperature greater than room temperature for a sufficient amount of time to form microparticles; and c) separating the microparticles from the reaction solution. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
-
Specification