Method of predicting carcinomic metastases

• US 5,579,766 A
• Filed: 07/31/1995
• Issued: 12/03/1996
• Est. Priority Date: 07/02/1992
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Gray, Lincoln C.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Layno, Carl H.
• Application Number:
  US08/509,302
• Time in Patent Office: 491 Days
• Field of Search: 128/653.1, 128/653.2, 128/898
• US Class Current: 600/407
• CPC Class Codes: A61B 10/00 Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis vaccination prophylaxis, vaccination therapy A61B17/20; Sex determination; Ovulation-period determination menstruation tables G06C3/00; Throat striking implements

Abstract

A method of predicting the locations of the lymph nodes most at risk of metastasis from a primary tumor associated with a cancer of the neck or head. The method utilizes data on the location of the primary tumor and the identity of lymph nodes to which the cancer has already spread. The data are transformated by a weighted multidimensional scaling (WMDS) process; points representing clusters of lymph nodes are placed in an imaginary mathematical space such that distances between points in that space are proportional to differences in the occurrence frequency of metastases.

Claims

1. A machine-executed method of generating a signal encoding the location of at-risk sites having an elevated risk of containing cancer cells in a patient having a primary tumor associated with a cancer, said method comprising:

(a) receiving a signal encoding the location of said primary tumor;

(b) generating a list of at-risk sites as a function of the location of the primary tumor;

(c) receiving signals respectively encoding metastatis indications for each of a subset of said at-risk sites;

(d) for each said at-risk site, computing an index of metastasis likelihood as a function of (1) the location of said primary tumor, and (2) the respective signal encoding a metastasis indicator for said at-risk site; and

(e) displaying said indices of metastasis likelihood and the respective locations of the associated at-risk sites.

2. The method of claim 1, wherein at least one of said at-risk sites is identified as a distant site.

3. The method of claim 1, wherein at least one of said at-risk sites is identified as a lymph node.

4. The method of claim 1, wherein said computing of an index of metastasis includes accounting for specific characteristics of said patient.

5. The method of claim 1, further comprising:

(f) receiving a signal encoding the stage of the cancer;

(g) recomputing said indices of metastasis for one or more of said at-risk sites as a function of the stage of the cancer;

(h) generating respective indices of predicted value of one or more additional exploratory procedures; and

(i) displaying at least one of said indices of predicted value.

6. The method of claim 1, further comprising receiving a signal encoding the extent of malignancy of said cancer.

7. The method of claim 6, further comprising comparing a characteristic of said signal encoding the extent of malignancy with said index of metastasis likelihood and determining whether said extent of malignancy is consistent with said index of metastasis likelihood and with established norms for the patient population, and if not, then signalling an abnormal condition on a signalling device.

8. The method of claim 6, further comprising recomputing said indices of metastasis for one or more at-risk sites as a function of the extent of malignancy.

9. The method of claim 8, further comprising repeating the operation described in claim 8 until the indices of metastasis likelihood in at-risk sites other than said inspected at-risk sites is less than a specified all-clear value.

10. The method of claim 9, further comprising generating an all-clear signal.

11. The method of claim 9, further comprising displaying an index of metastasis likelihood for each of one or more selected at-risk sites.

15. A program storage device readable by a machine of a specified one of claims 1 through 11 and encoding instructions that include instructions for the execution by said machine of the method of said claim.

12. A method of identifying the location, in a patient having observed metastases, of a hidden primary tumor associated with a cancer, said method comprising:

(a) determining the location of said one or more observed metastases;

(b) determining a set of one or more possible primary tumors that could have contributed one or more of the observed metastases;

(c) for each said possible primary tumor, computing an index of likelihood that the observed metastases arose from that possible primary tumor; and

(d) displaying said indices of likelihood and the respective locations of the associated possible primary tumors.

13. The method of claim 12, wherein said computing of an index of likelihood includes accounting for specific patient characteristics.

14. The method of claim 12, further comprising:

(e) generating respective indices of predicted value of one or more additional exploratory procedures;

(f) displaying at least one of said indices of predicted value;

(g) receiving additional metastases information generated by performance of one or more of said additional exploratory procedures;

(h) determining a new set of possible primary tumors as a function of said additional metastases information; and

(i) repeating the operations described in subparagraphs (c) and (d) of claim 12.