Method and apparatus for monitoring local cerebral physiology
First Claim
1. A probe, having a proximal and distal end, for intracranial monitoring of pressure and blood flow in a locus of a tissue medium proximately located at the distal end, said probe comprising:
- a first optical conductor, having one end located at said distal end and an opposite end located at said proximal end, that guides radiation to said distal end and guides radiation scattered from said tissue medium to said proximal end for providing a first indicative of the blood flow in the locus of the tissue medium; and
a second optical conductor, having one end including a pressure responsive means located at said distal end, adapted for generating an second optical signal at an opposite end located at said proximal end, said optical signal indicative of said pressure in the locus of the tissue medium;
wherein said first signal indicative of the blood flow in the locus of tissue medium and second optical signal indicative of said pressure in the locus of the tissue medium are measured substantially simultaneously and continuouslywherein sections of respective said optical conductors extending from said respective one ends of said first and second optical conductors, are movable together, providing an elongated integral section.
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Accused Products
Abstract
An apparatus for continuous monitoring of cerebral blood flow and intracranial pressure for substantially the same local region of cerebral tissue. A combined probe includes an elongated housing member that contains an ICP probe and a single optical fiber LDF microprobe. The LDF probe and the ICP probe are situated adjacent to each other within the elongated housing member, and preferably their respective intracranial ends are flush with the distal end of the elongated housing member. In addition, the combined probe is adapted to cooperate with an intracranial access system for securing the combined probe, and mitigating movement artifacts. In another embodiment, a combined probe includes a tissue oxymetry probe thus providing both metabolic and hemodynamic information for the same locus of cerebral tissue, and may be used for measuring a local cerebral metabolic rate. Another embodiment of the present invention provides a probe structure that includes a plurality of LDF microprobes for measuring CBF at spatially separate locations. In accordance with the present invention, a system and methods based on multi-modality monitoring, including monitoring of CBF and ICP for the same locus of cerebral tissue, are provided for measuring and assessing physiological processes and parameters including: autoregulation, cerebral vascular resistance (CVR), and carbon dioxide (CO2) reactivity.
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Citations
31 Claims
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1. A probe, having a proximal and distal end, for intracranial monitoring of pressure and blood flow in a locus of a tissue medium proximately located at the distal end, said probe comprising:
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a first optical conductor, having one end located at said distal end and an opposite end located at said proximal end, that guides radiation to said distal end and guides radiation scattered from said tissue medium to said proximal end for providing a first indicative of the blood flow in the locus of the tissue medium; and a second optical conductor, having one end including a pressure responsive means located at said distal end, adapted for generating an second optical signal at an opposite end located at said proximal end, said optical signal indicative of said pressure in the locus of the tissue medium; wherein said first signal indicative of the blood flow in the locus of tissue medium and second optical signal indicative of said pressure in the locus of the tissue medium are measured substantially simultaneously and continuously wherein sections of respective said optical conductors extending from said respective one ends of said first and second optical conductors, are movable together, providing an elongated integral section. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A probe for intracranial monitoring of pressure and blood flow at a local region of a tissue medium adjacently disposed to a distal end of said probe, comprising:
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pressure transducer means including a first optical fiber means and a pressure responsive member which cooperate to produce an first optical second signal indicative of said pressure in said local region of the tissue medium, said pressure responsive member located at one end of said first optical fiber means; and second optical fiber means for laser doppler flowmetry to provide a signal indicative of blood flow in said local region of the tissue medium, said second optical fiber means having one end movable together with, and adjacently disposed to, said one end of said first optical fiber means, thereby forming an elongated integral section;
wherein said first optical signal indicative of said pressure in said local region of the tissue medium and second signal indicative of blood flow in said local region of the tissue medium are measured substantially simultaneously and continuously. - View Dependent Claims (9)
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10. A probe apparatus for measuring intracranial pressure and blood flow in a locus of a tissue medium adjacently disposed to a distal end of said probe apparatus, comprising:
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a fixation member adapted for fixable mounting to a cranium having a bore, said fixation member having a lumen with proximal and distal openings, wherein said fixation member is adapted to be mounted to said cranium such that said lumen is aligned with said bore, said proximal opening disposed toward an exterior of said cranium and said distal opening disposed toward an interior of said cranium; an elongated housing member sized to be received within the lumen of said fixation member and having proximal and distal ends and at least one elongated passage with proximal and distal openings; a pressure transducer member including a first optical fiber member and a pressure responsive member which cooperate to produce an optical signal indicative of said pressure in said locus of the tissue medium, said pressure responsive member located at one end of said first optical fiber member, said pressure transducer member positioned at least partially within said at least one elongated passage with said pressure responsive member located at said distal end of said elongated housing member; and a second optical fiber member for laser doppler flowmetry of said medium to provide an optical signal indicative of blood flow in said locus of the tissue medium, said second optical fiber member positioned at least partially within said elongated passage, and having one end located at said distal end of said elongated housing member, whereby said signal indicative of blood flow and said signal indicative of pressure are both obtained from said locus of the tissue medium wherein said first optical signal indicative of said signal indicative of blood flow in said locus of the tissue medium are measured substantially simultaneously and continuously. - View Dependent Claims (11, 12, 13)
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14. A probe for intracranial monitoring of pressure and blood flow in substantially the same locus of a tissue medium adjacently disposed to a distal end of said probe, comprising:
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optical fiber means for laser doppler flowmetry of said medium to provide an optical signal indicative of blood flow in said locus of the tissue medium; and pressure transducer means coupled to said optical fiber means, said pressure transducer means including an optical fiber and a pressure responsive member for generating an optical signal indicative of said pressure in said locus of the tissue medium.
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- 15. A probe for use in measuring fluid flow at a plurality of local regions of a medium, comprising a plurality of optical fiber means for laser Doppler flowmetry of said medium, said plurality of optical fiber means fixably joined in a predetermined spatial relationship for guiding light to, and receiving backscattered light from, respective said plurality of local regions.
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17. A method for continuous monitoring of cerebrovascular blood flow and intracranial pressure of a local region of brain tissue, comprising the steps of:
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inserting a fixation means into a cranium, said fixation means having a lumen; inserting a probe through said lumen of said fixation means, thereby placing a distal end of said probe in proximity to brain tissue, wherein said probe is adapted for being received and secured by said fixation means, and wherein said probe includes a laser Doppler flowmetry probe and an intracranial pressure probe, said intracranial pressure probe having a pressure responsive member located at said distal end; illuminating said brain tissue by generating an optical signal which is guided by said laser Doppler flowmetry probe to be incident on said brain tissue; guiding an optical signal along said intracranial pressure probe to said pressure responsive member; receiving a backscattered optical signal from said tissue and guided by said laser Doppler flowmetry probe; receiving a reflected optical signal from said pressure responsive member and guided by said intracranial pressure probe; processing said backscattered optical signal to provide a signal indicative of blood flow within said brain tissue; and processing said reflected optical signal to generate a signal indicative of pressure within said brain tissue. - View Dependent Claims (18, 19, 20)
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21. A method for assessing autoregulation for a locus of brain tissue, comprising the steps of:
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acquiring a signal indicative of cerebral blood flow from said locus of brain tissue for a time interval; acquiring an intracranial pressure signal from the locus of brain tissue for the time interval; processing said signal indicative of cerebral blood flow to generate a cerebral blood flow signal; processing said intracranial pressure signal to generate a cerebral perfusion pressure signal; performing regression analysis between said cerebral perfusion pressure signal and said cerebral blood flow signal for said time interval to assess the statistical relationship between said cerebral perfusion pressure signal and said cerebral blood flow signal.
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22. A method for assessing carbon dioxide reactivity for a locus of brain tissue, comprising the steps of:
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acquiring a signal indicative of cerebral blood flow from said locus of brain tissue for a time interval; acquiring an end-tidal carbon dioxide signal from a respirator for the time interval; processing said signal indicative of cerebral blood flow to generate a cerebral blood flow signal; performing regression analysis between said cerebral blood flow signal and said end-tidal carbon dioxide signal for said time interval to assess statistical relationship between said cerebral blood flow signal and said end-tidal carbon dioxide signal.
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23. A probe for use in measuring oxygen content and fluid flow at a local region of a medium adjacently disposed to a distal end of said probe, comprising:
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optical fiber means for laser doppler flowmetry of said medium; tissue oxymetry transducer means, coupled to said optical fiber means, for generating a signal indicative of said oxygen content of said medium. - View Dependent Claims (24)
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25. A system for assessing patient status, comprising:
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monitoring means for receiving a plurality of signals, said signals including a signal indicative of cerebral blood flow for a local region of cerebral tissue, and a signal indicative of intracranial pressure for said local region acquired at a time substantially simultaneous to when said signal indicative of cerebral blood flow is acquired; processing means adapted to acquire from said monitoring means, and for processing, said plurality of signals to assess patient status. - View Dependent Claims (26, 27, 28, 29, 30)
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31. A system for assessing patient status, comprising:
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probe means for guiding to a local region of cerebral tissue, and receiving therefrom, respective optical signals for substantially continuous laser Doppler flowmetry, said probe means capable of being inserted at bedside into a cranium; means for receiving a plurality of signals, said signals including a substantially continuous signal indicative of cerebral blood flow corresponding to said probe means; and means for processing said plurality of signals to assess patient status.
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Specification