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Method and apparatus for producing thermodilution cardiac output measurements utilizing a neural network

  • US 5,579,778 A
  • Filed: 08/23/1994
  • Issued: 12/03/1996
  • Est. Priority Date: 09/09/1993
  • Status: Expired due to Term
First Claim
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1. A method for on-line calculation of cardiac output of a patient, said method comprising the steps of:

  • 1.1) coupling at least one sensor to the patient, said sensor being responsive to register changes in blood temperature as part of a thermodilution procedure which includes bolus injection without volume loading of the patient;

    1.2) activating the sensor to generate a sequence of on-line signals which register changes occurring in the blood temperature of a patient through direct indicator dilution signal measurements;

    1.3) transmitting the on-line signals as input signals to a computer system, including input nodes of a neural network supported by the computer system, which neural network is capable of calculating a continuous output signal corresponding to a parameter value from the on-line, input signals;

    1.4) preprocessing the input signals to produce a scaled waveform;

    1.5) processing the input signals within the neural network to convert the sequence of input signals to an on-line output signal corresponding to a cardiac output value by applying fixed weighting factors to the input signals; and

    1.6) retrieving said fixed weighting factors which were previously generated by applying a training algorithm with respect to previously collected training data comprising neural network input signals and corresponding known cardiac output values.

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