Method of conveying liquid materials and device for the automated elution of a radionuclidic generator
First Claim
1. A method of conveying different liquid materials, including a first liquid material and a second liquid material, in a closed system without mutual contamination, comprising the steps of (i) introducing the first liquid material into a main conduit through a first inflow conduit-provided with a first valve for conveyance through the main conduit in a conveying direction, (ii) closing said first valve and flushing said main conduit in the conveying direction with an inert gas, (iii) stopping the flushing operation and introducing a second liquid material into said main conduit through a second inflow conduit provided with a second valve for conveyance through the main conduit in a conveying direction, and (iv) closing said second valve and repeating said flushing operation, characterized in that the main conduit comprises flexible disposable tubing, that the steps of introducing the first liquid material and of introducing the second liquid material into the main conduit are effected with the aid of a peristaltic pump disposed downstream in the conveying direction from the first valve and from the second valve and acting in the conveying direction on flexible disposable tubing of the main conduit, that the first inflow conduit and the second inflow conduit each comprise flexible disposable tubing between the respective valve and the junction of the respective inflow conduit with the main conduit, and that after each flushing operation the peristaltic pump is made to operate in a direction opposite to the conveying direction for a short period sufficient to cause the position of the surface of a potentially contaminating outer surface (a) of an aliquot of liquid in the respective inflow conduit to change to a non-contaminating position (b).
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Abstract
The invention relates to a method of conveying liquid materials in closed systems without mutual contamination, comprising flushing the conduit with an inert gas between introduction of the materials into said conduit and using a peristaltic pump for introducing said materials, in which after each flushing operation for a moment said pump is made to rotate in the reverse direction.
The invention further relates to a method for the automated elution of a radionuclide generator and delivery of a radiopharmaceutical liquid, in particular a Tc99m-pertechnetate solution, whereas said above method is used, and to a device for performing said method for elution and delivery of a radiopharmaceutical liquid.
55 Citations
6 Claims
- 1. A method of conveying different liquid materials, including a first liquid material and a second liquid material, in a closed system without mutual contamination, comprising the steps of (i) introducing the first liquid material into a main conduit through a first inflow conduit-provided with a first valve for conveyance through the main conduit in a conveying direction, (ii) closing said first valve and flushing said main conduit in the conveying direction with an inert gas, (iii) stopping the flushing operation and introducing a second liquid material into said main conduit through a second inflow conduit provided with a second valve for conveyance through the main conduit in a conveying direction, and (iv) closing said second valve and repeating said flushing operation, characterized in that the main conduit comprises flexible disposable tubing, that the steps of introducing the first liquid material and of introducing the second liquid material into the main conduit are effected with the aid of a peristaltic pump disposed downstream in the conveying direction from the first valve and from the second valve and acting in the conveying direction on flexible disposable tubing of the main conduit, that the first inflow conduit and the second inflow conduit each comprise flexible disposable tubing between the respective valve and the junction of the respective inflow conduit with the main conduit, and that after each flushing operation the peristaltic pump is made to operate in a direction opposite to the conveying direction for a short period sufficient to cause the position of the surface of a potentially contaminating outer surface (a) of an aliquot of liquid in the respective inflow conduit to change to a non-contaminating position (b).
Specification