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Chemical functionalization of surfaces

  • US 5,580,697 A
  • Filed: 06/23/1994
  • Issued: 12/03/1996
  • Est. Priority Date: 01/21/1993
  • Status: Expired due to Fees
First Claim
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1. A method for producing a functionalized surface on a substance, comprising the steps:

  • (a) providing a non-fluid substrate having a surface comprising surface molecules having chemical moieties each capable of undergoing an addition reaction with a nitrene;

    (b) providing a first functionalizing reagent comprising molecules each having a nitrenogenic group and a first functional group, the first functionalizing reagent being selected from the group consisting of functionalized perfluorophenyl azides having the structure;

    ##STR22## wherein X is selected from the group consisting of CN;

    CONH2 ;

    CHO;

    CO2 CH3 ;

    COCH3 ;

    NO2 ;

    CO2 H;

    COCl;

    CO-imidazole;

    CONHS;

    CH2 OH;

    CH2 NH2 ;

    COCH2 Br;

    N-maleimido;

    NH-biotinyl;

    CONH--R, wherein R is a polypeptide;

    CONH--X--S--S--Y--NH-biotinyl, wherein X and Y are spacer atoms; and

    CONHS--SO3 Na;

    (c) applying the first functionalizing reagent to the substrate surface; and

    (d) either subsequent to or simultaneously with step (c), exposing preselected regions on the substrate surface to a reaction-energy source so as to convert the nitrenogenic groups, on molecules of the first functionalizing reagent on the surface, to nitrenes that undergo addition reactions with the chemical moieties on the surface molecules, thereby covalently bonding the first functional groups to the surface molecules to create a pattern of functionalized surface regions relative to non-functionalized regions.

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