Substituted tryptamines phenalkylamines and related compounds

• US 5,580,878 A
• Filed: 06/07/1995
• Issued: 12/03/1996
• Est. Priority Date: 04/05/1994
• Status: Expired due to Fees

• Current Assignee: Interneuron Pharmaceuticals, Inc. (Endo International PLC)
• Original Assignee: Interneuron Pharmaceuticals, Inc. (Endo International PLC)
• Inventors: Bellott, Emile M., Al-Farhan, Emile, Krishnananthan, Subramaniam, Nohrden, Michael D., D'Orlando, Kay J., Locke, Kenneth W., Sachdeva, Yesh P., Gabriel, Richard L., Zahr, Salah A.
• Primary Examiner(s): MCKANE, JOSEPH K
• Application Number:
  US08/486,788
• Time in Patent Office: 545 Days
• Field of Search: 514/292, 546/85, 546/86
• US Class Current: 514/292
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: C07C 2601/02 with a three-membered ring
• CPC Class Codes: C07C 2601/04 with a four-membered ring
• CPC Class Codes: C07C 2601/08 the ring being saturated
• CPC Class Codes: C07D 207/08 with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
• CPC Class Codes: C07D 209/16 Tryptamines
• CPC Class Codes: C07D 317/54 Radicals substituted by oxygen atoms
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

This invention relates to novel substituted tryptamine and phenalkylamine and related compounds, pharmaceutical compositions thereof and methods of using said compounds.

Claims

1. A method of treating mammals for sleep disorders comprising the step of administering a therapeutically effective amount of 2-acetyl-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.

2. A method of treating mammals for sleep disorders comprising the step of administering a therapeutically effective amount of 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.

3. A pharmaceutical composition useful for treating sleep disorders which composition comprises a therapeutically effective amount of 2-acetyl-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.

4. A pharmaceutical composition useful for treating sleep disorders which composition comprises a therapeutically effective amount of 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.

5. A compound which is 6-benzyl-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.

6. A method of treating mammals for sleep disorders comprising the step of administering a therapeutically effective amount of the compound of claim 5.

7. A pharmaceutical composition useful for treating sleep disorders which composition comprises a therapeutically effective amount of the compound of claim 5.

8. A method of treating mammals for sleep disorders comprising the step of administering a therapeutically effective amount of 6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.