Method for the comminution of concretions

• US 5,582,578 A
• Filed: 08/01/1995
• Issued: 12/10/1996
• Est. Priority Date: 08/01/1995
• Status: Expired due to Term

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Cocks, Franklin H., Zhong, Pei, Preminger, Glenn M.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/509,770
• Time in Patent Office: 497 Days
• Field of Search: 310/334, 310/322, 310/337, 310/335, 601/2, 601/3, 601/4, 128/660.03, 607/97, 604/20, 604/22
• US Class Current: 601/4
• CPC Class Codes: A61B 17/225 for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
• CPC Class Codes: A61B 2017/00176 Two pulses, e.g. second pulse having an effect different from the first one
• CPC Class Codes: A61B 2017/22008 used or promoted

Abstract

The invention relates to a method for the comminution of concretions in vivo by controlled, concentrated cavitation energy. This method utilizes two shock wave pulses with a specified time delay and pressure relationship, with the first shock wave pulse being used to induce a transient cavitation bubble cluster near the target concretion, and the second shock wave pulse to control and force the collapse of the cavitation bubble cluster towards the target concretion with concentrated energy deposition, while avoiding injury to surrounding tissue caused by random collapse of the cavitation bubbles. This invention makes it possible to significantly enhance the fragmentation efficiency of the concretion using shock waves while reducing potential deleterious injury to surrounding tissue.

Claims

1. A method for comminuting concretions located within a living body, said method consisting essentially of the steps of

(a) producing a first shock wave pulse in a liquid, said first shock wave pulse having a compressive phase with a peak amplitude whose magnitude is greater than 20 million pascals and with a duration of 1 to 2 microseconds, and said first shock wave pulse having a tensile phase with a peak amplitude whose magnitude is greater than 1 million pascals and with a duration of 2 to 5 microseconds,

(b) focussing said first shock wave pulse to produce a transient cavitation bubble cluster in a volume embracing said concretions, said volume being less than 65 cubic centimeters,

(c) producing a second shock wave pulse in said liquid, said second shock wave pulse being produced after a time delay that is between 50 and 400 microseconds after said first shock wave pulse, said second shock wave pulse having a compressive phase with a peak amplitude whose magnitude is between 2 and 100 million pascals and with a duration between 2 and 40 microseconds,

(d) focussing said second shock wave pulse in said volume, whereby said transient acoustic cavitation bubble clusters are forced to collapse by said second shock wave pulse thereby producing liquid jets, said jets impinging on said concretions, whereby said concretion comminution is increased.

2. A method as disclosed in claim 1, wherein said first acoustic pulse is produced by means of a shock wave generation system selected from the group of shock wave generation systems consisting of electrohydraulic, electromagnetic, and piezoelectric shock wave generation systems.

3. A method as disclosed in claim 1, wherein said second shock wave pulse is produced by means of the superposition of shock wave pulses of different amplitudes, frequencies, and phases, produced by energizing of an array of piezoelectric elements mounted on an inner surface of a spherical cap with said energizing of said piezoelectric elements being controlled electronically.

4. A method as disclosed in claim 1, wherein said liquid is water and said liquid jets are water jets.

5. A method for comminuting concretions located within a living body, separated from a surface of said living body by interposed tissue, said method consisting essentially of the steps of

(a) producing a test shock wave pulse in a liquid, said test shock wave pulse having a compressive phase with a peak amplitude whose magnitude is greater than 20 million pascals and with a duration of 1 to 2 microseconds, and said first shock wave pulse having a tensile phase with a peak amplitude whose magnitude is greater than 1 million pascals and with a duration of 2 to 5 microseconds,

(b) focussing said test shock wave pulse to produce a test transient cavitation bubble cluster, said test transient cavitation bubble cluster producing an acoustic emission through an initial expansion, subsequent collapse and rebound of said test transient cavitation bubble cluster in a volume embracing said concretions, said volume being less than 65 cubic centimeters,

(c) measuring said acoustic emission produced by said test transient cavitation bubble cluster, induced by said test shock wave pulse, and determining a duration of growth of said test transient cavitation bubble cluster,

(d) producing a first shock wave pulse in said liquid, said first shock wave pulse having a compressive phase with a peak amplitude whose magnitude is greater than 20 million pascals and with a duration of 1 to 2 microseconds, said first shock wave pulse having a tensile phase with a peak amplitude whose magnitude is greater than I million pascals and with a duration of 2 to 5 microseconds,

(e) focussing said first shock wave pulse to produce a transient cavitation bubble cluster in a volume embracing said concretions, said volume being less than 65 cubic centimeters,

(f) producing a second shock wave pulse in sequence to said first shock wave pulse in said liquid, said second shock wave pulse having a compressive phase with a peak amplitude whose magnitude is between 2 and 100 million pascals and with a duration between 2 and 40 microseconds, said second shock wave pulse being produced at a specified time delay after said production of said first shock wave pulse, said specified time delay being equal to said duration of growth of said test transient cavitation bubble cluster,

(g) focussing said second shock wave pulse in said volume, whereby said transient acoustic cavitation bubble clusters are collapsed by said second shock wave pulse thereby producing liquid jets, said jets impinging on said concretions, whereby said concretion is comminuted.

6. A method for comminuting concretions as disclosed in claim 5, wherein said acoustic emission is measured by using a passive cavitation detector, said duration of growth of said test transient cavitation bubble cluster being determined by an ultrasound analyzer.

7. A method for comminuting concretions as disclosed in claim 5, wherein said specified time delay between said production of said first shock wave pulse and said production of said second shock wave pulse, is determined using a time delay generator, a trigger system and a high-voltage supply connected with said shock wave generation system, based on said duration of growth of said test transient cavitation bubble cluster.

8. A method for comminuting concretions as disclosed in claim 5, wherein said liquid is water and said liquid jets are water jets.

9. A method for comminuting concretions located within a living body, said method consisting essentially of the steps of

(a) producing a first shock wave pulse in a liquid, said first shock wave pulse having a compressive phase with a peak amplitude whose magnitude is greater than 20 million pascals and with a duration of 1 to 2 microseconds, and said first shock wave pulse having a tensile phase with a peak amplitude whose magnitude is greater than I million pascals and with a duration of 2 to 5 microseconds,

(b) focussing said first shock wave pulse to produce a transient cavitation bubble cluster in a volume embracing said concretions with said volume being less than 65 cubic centimeters,

(c) producing a second shock wave pulse in said liquid, said second shock wave pulse being produced after a time delay that is between 50 and 400 microseconds after said first shock wave pulse, said second shock wave pulse having a compressive phase with a peak amplitude whose magnitude is between 2 and 100 million pascals and with a duration between 2 and 40 microseconds,

(d) sending said first shock wave pulse and said second shock wave pulse produced by said shock wave generation system along different pathways in said interposed tissue before arriving at said concretions,

(e) focussing said second shock wave pulse in said volume, whereby said transient acoustic cavitation bubble clusters are forced to collapse by said second shock wave pulse thereby producing liquid jets, said jets impinging on said concretions, whereby said concretion is comminuted.

10. A method for comminuting concretions as disclosed in claim 9, wherein said first shock wave pulse and said second shock wave pulse propagate along coaxial pathways.

11. A method for comminuting concretions as disclosed in claim 9, wherein said first shock wave pulse and said second shock wave pulse propagate along said different pathways in said interposed tissue before arriving at a common focus which has a volume less than 65 cubic centimeters.

12. A method for comminuting concretions as disclosed in claim 9, wherein said liquid is water and said liquid jets are water jets.