Hyaluronic acid-urea pharmaceutical compositions and uses

• US 5,583,120 A
• Filed: 06/02/1995
• Issued: 12/10/1996
• Est. Priority Date: 08/04/1993
• Status: Expired due to Fees

• Current Assignee: Surrogate Pharmaceutical Pathways, LLC
• Original Assignee: Patent Biopharmaceutics, Inc.
• Inventors: Gallina, Damian J.
• Primary Examiner(s): Lilling, Herbert J.
• Application Number:
  US08/471,332
• Time in Patent Office: 557 Days
• Field of Search: 514/54, 514/588, 514/859, 514/860, 514/882, 514/912, 514/944, 536/55.1
• US Class Current: 514/54
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/735 Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C07H 5/04 to nitrogen

Abstract

This invention includes a pharmaceutical composition including a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically salt thereof. The invention also includes a method of treating disease of the cutis which includes applying to cutis tissues in need of such treatment a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically acceptable salt thereof, said disease having symptoms selected from the group consisting of inflammation, erythema, edema, papules, vesicles, macules, pustules, scaling, cracking, crusting, and lesions. The invention further includes methods for the treatment of psoriasis, eczema, dermatitis, herpetic conditions, acne, skin ulcers, genital herpes lesions and anorectal disease, which includes applying to tissues in need of such treatment a therapeutically effective amount of a composition including a pharmaceutically acceptable carrier, urea and hyaluronic acid or a pharmaceutically acceptable salt thereof.

Claims

1. A method of treating dermatitis which comprises applying to cutis tissues in need of such treatment a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, urea in an amount of 0.1-40% by weight, and hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount of 0.05-25% by weight.

2. The method of claim 1 wherein said composition further includes an additive selected from the group consisting of keratolytics, surfactants, counter-irritants, humectants, antiseptics, lubricants, astringents, emulsifiers, wetting agents, wound healing agents, adhesion/coating protectants, vasoconstrictors, anticholinergics, corticosteroids, anesthetics and anti-inflammatory agents.

3. The method of claim 1 wherein said composition is in a form selected from the group consisting of cream, lotion, gel, ointment, solid, paste, salve, powder, liquid, spray and aerosol.

4. The method of claim 1 wherein said carrier is water.

5. The method of claim 1 wherein said pharmaceutically acceptable salt is sodium hyaluronate.

6. The method of claim 1 wherein said composition includes urea in an amount of 0.1-30% by weight and hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount of 0.05-15% by weight.

7. The method of claim 1 wherein said composition includes urea in an amount of 0.5-30% by weight and hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount of 0.1-10% by weight.

8. The method of claim 1 wherein said composition includes urea in an amount of 1.0-25% by weight and hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount of 0.5-5.0% by weight.