Multi-head nuclear medicine camera for dual SPECT and PET imaging

• US 5,585,637 A
• Filed: 06/09/1995
• Issued: 12/17/1996
• Est. Priority Date: 06/09/1995
• Status: Expired due to Term

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Adam Laboratories Inc.
• Inventors: Wellnitz, Donald R., Bertelsen, Hugo, Murphy, Matthew J., Hines, Horace H., Nellemann, Peter
• Primary Examiner(s): Hannaher, Constantine
• Application Number:
  US08/488,926
• Time in Patent Office: 557 Days
• Field of Search: 250/363.03, 250/363.04, 250/369
• US Class Current: 250/363.03
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/2985 In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02

Abstract

A multi-detector head nuclear camera system automatically switchable (and optimized) to perform either SPECT imaging or PET imaging. The camera system employs, in one embodiment, multi-detector configuration having dual head scintillation detectors but can be implemented with more than two detector heads. The detectors contain switchable triggering circuitry so that coincidence detection for PET imaging and non-coincidence detection for SPECT imaging is available. Using a variable integration technique with programmable integration interval, the event detection and acquisition circuitry of the camera system is switchable to detect events of different energy distribution and count rate which are optimized for PET and SPECT imaging. The system also includes dual integrators on each scintillation detector channel for collecting more than one event per detector at a time for PET or SPECT mode. In PET or SPECT mode, the system also employs variable PMT cluster sizing having smaller cluster sizes for PET imaging and relatively larger cluster sizes for SPECT. In PET or SPECT mode, the system also employs variable centroid shape and zonal triggering. Utilizing the above programmable settings, the camera system can be automatically configured to operate in either SPECT or PET imaging modes.

Claims

1. A nuclear camera system comprising:

a first detector and a second detector for detecting scintillation events, said first detector and said second detector coupled to an acquisition computer system;

a input mechanism for selecting between a PET imaging mode and a SPECT imaging mode;

a switchable trigger detection unit that is automatically switchable between coincidence detection when said PET imaging mode is selected and non-coincidence detection when said SPECT imaging mode is selected;

said switchable trigger detection unit coupled to supply a first valid event trigger signal to said first detector causing said first detector to record a scintillation event and coupled to supply a second valid event trigger signal to said second detector causing said second detector to record a scintillation event.

2. A nuclear camera system as described in claim 1 wherein:

said first detector and said second detector individually comprise event detection units for transmitting indications of scintillation events to said switchable trigger detection unit; and

wherein

said switchable trigger detection unit generates said first and second valid event trigger signals upon detection of two indications of scintillation events occurring within a coincidence window, one in said first detector and one said second detector, provided said PET imaging mode is selected.

3. A nuclear camera system as described in claim 2 wherein each event detection unit of said event detection units correspond to a zonal area of said first or second detector and each event detection unit generates an indication of scintillation events occurring within a corresponding zonal area of said first or second detector.

4. A nuclear camera system as described in claim 3 wherein said event detection units utilize constant fraction discriminators to generate said indications of scintillation events.

5. A nuclear camera system as described in claim 1 wherein:

said first detector and said second detector individually comprise event detection units for transmitting indications of scintillation events to said switchable trigger detection unit; and

wherein

said switchable trigger detection unit generates said first valid event trigger signal upon receiving an indication of a scintillation event occurring within said first detector and generates said second valid event trigger signal upon receiving an indication of a scintillation event occurring within said second detector, provided said SPECT imaging mode is selected.

6. A nuclear camera system as described in claim 5 wherein each event detection unit of said event detection units correspond to a zonal area of said first or second detector and each event detection unit generates an indication of scintillation events occurring within a corresponding zonal area of said first or second detector.

7. A nuclear camera system as described in claim 6 wherein said event detection units utilize leading edge discriminators to generate said indications of scintillation events.

8. A nuclear camera system as described in claim 1 wherein:

said first detector comprises PET event detection units for transmitting indications of scintillation events occurring within said first detector to said switchable trigger detection unit;

said second detector comprises PET event detection units for transmitting indications of scintillation events occurring within said second detector to said switchable trigger detection unit; and

wherein

said switchable trigger detection unit comprises a coincidence detector coupled to said indications of scintillation events occurring within said first detector and coupled to said indications of scintillation events occurring within said second detector, said coincidence detector for generating a coincidence signal upon coincidence of said scintillation events occurring within said first detector and said indications of scintillation events occurring within said second detector.

9. A nuclear camera system as described in claim 8 wherein:

said first detector comprises SPECT event detection units for transmitting indications of scintillation events occurring within said first detector to said switchable trigger detection unit; and

said second detector comprises SPECT event detection units for transmitting indications of scintillation events occurring within said second detector to said switchable trigger detection unit.

10. A nuclear camera system as described in claim 9 wherein said switchable trigger detection unit further comprises:

a first multiplexer receiving a select signal and receiving an input from said SPECT event detection units of said first detector and receiving an input from said coincidence detector;

a second multiplexer receiving said select signal and receiving an input from said SPECT event detection units of said second detector and receiving an input from said coincidence detector; and

wherein said first multiplexer outputs said first valid event trigger signal to said first detector and wherein said second multiplexer outputs said second valid event trigger signal to said second detector.

11. A trigger signal generator switchable between PET and SPECT operational modes, said trigger signal generator comprising:

first SPECT event detection circuitry for generating a first trigger signal upon detection of a scintillation event within a first detector;

second SPECT event detection circuitry for generating a second trigger signal upon detection of a scintillation event within a second detector;

first PET event detection circuitry for generating a third trigger signal upon detection of a scintillation event within said first detector;

second PET event detection circuitry for generating a fourth trigger signal upon detection of a scintillation event within said second detector;

a coincidence detector coupled to said third and fourth trigger signals for generating a coincidence signal upon coincidence of said third and fourth trigger signals; and

a switchable unit receiving said coincidence signal and said first and second trigger signals, said switchable unit for providing said first and second detector with said coincidence signal when in said PET operational mode and for providing said first and second detector with said first and second trigger signals, respectively, when in said SPECT operational mode.

12. A trigger signal generator as described in claim 11 wherein said switchable unit receives a select signal indicating either said PET or said SPECT operational mode.

13. A trigger signal generator as described in claim 12 wherein said switchable unit further comprises:

a first multiplexer receiving said select signal and said first trigger signal and said coincidence signal and outputting a valid event signal to said first detector;

a second multiplexer receiving said select signal and said second trigger signal and said coincidence signal and outputting a valid event signal to said second detector;

said first multiplexer outputting said first trigger signal as said valid event signal to said first detector when in said SPECT operational mode and outputting said coincidence signal as said valid event signal to said first detector when in said PET operational mode; and

said second multiplexer outputting said second trigger signal as said valid event signal to said second detector when in said SPECT operational mode and outputting said coincidence signal as said valid event signal to said second detector when in said PET operational mode.

14. A trigger signal generator as described in claim 11 wherein said switchable unit triggers said first and second detectors to record a detected scintillation event, including accumulating energy of said scintillation event and localizing said scintillation event.

15. A trigger signal generator as described in claim 11 wherein said first and second SPECT event detection circuitry utilize a leading edge discriminator and wherein said first and second PET event detection circuitry utilize a constant fraction discriminator.

16. For a channel circuit associated with a photomultiplier of a scintillation detector, an accumulator circuit comprising:

a programmable register for containing a programmable integration period;

an analog to digital converter for receiving a first signal representative of energy detected by said photomultiplier as a result of a scintillation event and for digitizing said first signal to generate a digital signal therefrom;

a first integrator for integrating said digital signal over said programmable integration period to arrive at a result;

a memory circuit for containing said result of said first integrator.

17. An accumulator circuit as described in claim 16 further comprising a programming unit for programming a first integration period into said programmable register such that said first integrator is optimized for periods of higher count rate and for programming a second integration period into said programmable register such that said first integrator is optimized for periods of lower count rate.

18. An accumulator circuit as described in claim 17 wherein a received trigger signal initiates an integration interval and further comprising:

a counter circuit for counting an interval from said trigger signal;

a comparator circuit coupled to said counter circuit and coupled to said programmable register, said comparator circuit generating an output signal when said counter circuit reaches said programmable integration period; and

said memory circuit for latching in said result upon generation of said output signal from said comparator circuit.

19. An accumulator circuit as described in claim 16 further comprising:

a programming unit for programming said programmable integration period such that said first integrator is optimized first a PET operational mode.

20. An accumulator circuit as described in claim 19 further comprising:

a programming unit for programming said programmable integration period such that said first integrator is optimized for a SPECT operational mode.

21. An event detection apparatus comprising:

(a) at least a pair of scintillation detectors for reporting a pair of events occurring in coincidence for PET imaging and for reporting events individually for SPECT imaging, each of said pair of scintillation detectors comprising;

(i) an analog to digital converter for receiving a channel signal representative of energy detected by a photomultiplier as a result of a scintillation event and for digitizing said channel signal to generate a digital signal therefrom;

(ii) a first integrator circuit coupled to receive said digital signal and for integrating said digital signal over a first time period of a programmable integration interval;

(iii) a second integrator circuit coupled to said digital signal and for integrating said digital signal over a second time period of said programmable integration duration; and

(iv) a programmable register for containing a value representative of said programmable integration duration; and

(b) a mechanism for recording said events.

22. An event detection apparatus as described in claim 21 further comprising a programming unit for programming a first value into said programmable register such that said first and second integrator circuits are optimized for periods of higher count rate detection and for programming a second value into said programmable register such that said first and second integrator circuits are optimized for periods of lower count rate detection.

23. An event detection apparatus as described in claim 21 wherein a received trigger signal initiates an integration interval and further comprising:

a first counter circuit for counting an interval from said trigger signal;

a first comparator circuit coupled to said first counter circuit and coupled to said programmable register, said first comparator circuit generating a first output signal when said first counter circuit reaches said programmable integration interval;

a memory circuit for latching in a result of said first integrator circuit upon generation of said first output signal from said first comparator circuit.

a second counter circuit for counting an interval from said trigger signal;

a second comparator circuit coupled to said second counter circuit and coupled to said programmable register, said second comparator circuit generating a second output signal when said second counter circuit reaches said programmable integration interval; and

said memory circuit for latching in a result of said second integrator circuit upon generation of said second output signal from said second comparator circuit.

24. An event detection apparatus as described in claim 21 wherein said first integrator circuit and said second integrator circuit operate such that said first time period and said second time period overlap.

25. An event detection apparatus as described in claim 21 further comprising a trigger circuit for generating a trigger pulse upon detection of a gamma event and wherein said first integrator circuit and said second integrator circuit are independently initiated by said trigger circuit.

26. An event detection apparatus as described in claim 25 further comprising a two stage latch circuit coupled to receive output data from both of said first integrator circuit and said second integrator circuit, said two stage latch circuit for containing integrated results of said digital signal.

27. An event detection apparatus as described in claim 26 further comprising a multiplexer circuit for selecting an output between said first integrator circuit and said second integrator circuit and for supplying said output to said two stage latch circuit.

28. An event detection apparatus as described in claim 26 wherein said two stage latch circuit comprises:

a first memory stage for receiving output data from both of said first integrator circuit and said second integrator circuit; and

a second memory stage coupled to said first memory stage for receiving output data from said first stage when said first stage receives said output data from said first integrator circuit or said second integrator circuit.

29. In a nuclear medicine camera, an apparatus for generating a photomultiplier cluster, said apparatus comprising:

at least a pair of scintillation detectors for reporting a pair of events occurring in coincidence for PET imaging and for reporting events individually for SPECT imaging, each of said pair of scintillation detectors comprising;

an array of photomultipliers wherein individual photomultipliers generate channel signals,

integration circuitry integrating said channel signals from each scintillation detector responsive to a gamma event and generating integration results therefrom;

peak circuitry for determining a peak photomultiplier based on said integration results and for generating a signal indicative of said peak photomultiplier; and

cluster circuitry addressed by said peak circuitry and responsive to said signal indicative of said peak photomultiplier for generating a photomultiplier cluster associated with said peak photomultiplier, said cluster circuitry containing separate photomultiplier clusters for individual photomultipliers of said array of photomultipliers and wherein said cluster circuitry also generates a cluster type signal responsive to said signal indicative of said peak photomultiplier wherein said cluster type signal indicates a geometric type of said photomultiplier cluster.

30. An apparatus as described in claim 29 wherein said photomultiplier cluster comprises a set of photomultiplier indicators and further comprising:

a sequencer circuit coupled to said cluster circuitry, said sequencer circuit for addressing said cluster circuitry such that individual photomultiplier indicators of said photomultiplier cluster are sequentially output from said cluster circuitry; and

weight circuitry responsive to (1) said photomultiplier indicators and (2) said cluster type signal, said weight circuitry for generating individual coordinate weight value signals associated with individual photomultipliers of said photomultiplier cluster.

31. An apparatus as described in claim 30 wherein said photomultiplier cluster comprises a set of photomultiplier indicators and further comprising:

a buffer storage for storing integrated results of said photomultiplier cluster, said buffer storage addressed by photo multiplier indicators output from said cluster circuitry; and

centroid computation circuitry coupled to receive output integration results from said buffer storage and coupled to receive said individual coordinate weight value signals associated with individual photomultipliers of said photomultiplier cluster, and in response thereto, said centroid computation circuitry for generating a two dimensional spatial coordinate of said gamma event.

32. An apparatus as described in claim 29 wherein said cluster type signal indicates between a normal cluster type, an edge cluster type and a comer cluster type of said photomultiplier cluster.

33. An apparatus as described in claim 29 wherein said photomultiplier cluster comprises a set of photomultiplier indicators and further comprising a sequencer circuit coupled to said cluster circuitry, said sequencer circuit for addressing said cluster circuitry such that individual photomultiplier indicators of said photomultiplier cluster are sequentially output from said cluster circuitry.

34. An apparatus as described in claim 33 wherein said cluster circuitry comprises a programmable memory circuit addressed by said signal indicative of said peak photomultiplier and said sequencer circuit.

35. An apparatus as described in claim 29 further comprising a user selectable operational mode between said PET imaging and said SPECT imaging wherein said photomultiplier cluster that is output from said cluster circuitry is responsive to said operational mode.

36. An apparatus as described in claim 35 wherein said cluster circuitry outputs photomultiplier clusters in sets of seven or less photomultipliers each, provided said operational mode is set for said PET imaging and wherein said cluster circuitry outputs photomultiplier clusters in sets of more than seven photomultipliers each, provided said operational mode is set for said SPECT imaging.

37. In a nuclear medicine camera, an apparatus for generating a photomultiplier cluster, said apparatus comprising:

(a) a user selectable operational mode between PET imaging and SPECT imaging;

(b) at least a pair of scintillation detectors for reporting a pair of events occurring in coincidence for said PET imaging and for reporting events individually for said SPECT imaging, each of said pair of scintillation detectors comprising;

an array of photomultipliers, individual photomultipliers for generating output channel signals indicative of energy detected by said individual photomultipliers;

peak circuitry coupled to receive said output channel signals and for determining a peak photomultiplier of said array of photomultipliers; and

cluster circuitry addressed by said peak circuitry and responsive to said signal indicative of said peak photomultiplier for generating a photomultiplier cluster associated with said peak photomultiplier, said cluster circuitry containing separate photomultiplier clusters for each peak photomultiplier, said cluster circuitry for providing photomultiplier clusters of a first size provided said operational mode is said PET imaging and for providing photomultiplier clusters of a second size provided said operational mode is said SPECT imaging; and

(c) a mechanism for recording said events detected by said pair of scintillation detectors.

38. An apparatus as described in claim 37 wherein said first size is relatively smaller than said second size.

39. An apparatus as described in claim 37 wherein said first size is 7 or less photomultipliers per cluster and wherein said second size is more than 7 photomultipliers per cluster.

40. In a nuclear medicine camera, an apparatus for generating a trigger signal indicative of an event, said apparatus comprising:

(a) a user selectable operational mode between PET imaging and SPECT imaging;

(b) at least a pair of scintillation detectors for reporting a pair of events occurring in coincidence for said PET imaging and for reporting events individually for said SPECT imaging, each of said pair of scintillation detectors comprising;

an array of photomultipliers, individual photomultipliers for generating output channel signals indicative of energy detected by said individual photomultipliers, wherein said array of photomultipliers is divided into zones;

a first plurality of event detection circuits wherein each of said event detection circuits receive channel signals from a particular zone of said zones of said array of photomultipliers; and

a first trigger circuit coupled to said first plurality of event detection circuits for generating a trigger signal upon receiving an event indication from any event detection circuit of said first plurality of event detection circuits.

41. An apparatus as described in claim 40 wherein each of said event detection circuits of said first plurality comprise a constant fraction discriminator for generating an event indication.

42. An apparatus as described in claim 40 further comprising:

an AND gate coupled to each first trigger circuit of said pair of scintillation detectors, said AND gate generating a valid event trigger signal upon receiving a pair of trigger signals within a coincidence window from each first trigger circuit of said pair of scintillation detectors.

43. An apparatus as described in claim 40 wherein said pair of scintillation detectors further comprise:

a second plurality of event detection circuits wherein each of said event detection circuits of said second plurality receive channel signals from a particular zone of said zones of said array of photomultipliers; and

a second trigger circuit coupled to said second plurality of event detection circuits for generating a trigger signal upon receiving an event indication from any event detection circuit of said second plurality of event detection circuits.

44. An apparatus as described in claim 43 wherein each of said event detection circuits of said second plurality comprise a leading edge discriminator for generating an event indication.

45. An apparatus as described in claim 43 further comprising:

an OR gate coupled to each second trigger circuit of said pair of scintillation detectors, said OR gate generating a valid event trigger signal upon receiving a trigger signal from either of said second trigger circuits of said pair of scintillation detectors.

46. In a nuclear medicine camera, an apparatus for optimizing said camera for either PET or SPECT imaging modes, said apparatus comprising:

a switchable operational mode between said PET imaging and said SPECT imaging modes;

at least a pair of scintillation detectors for reporting a pair of events occurring in coincidence for said PET imaging mode and for reporting events individually for said SPECT imaging mode, said pair of scintillation detectors for rotating about a patient and for collecting projection image data under said PET or SPECT imaging modes;

programmable integration circuitry coupled to channel signals output from photomultiplier tubes of said pair of scintillation detectors, said programmable circuitry for integrating said channel signals over a first integration period or over a second integration period in response to said operational mode;

a programmable trigger circuit coupled to event detection logic within said pair of scintillation detectors, said programmable trigger circuit for generating valid event trigger signals based on coincidence between said pair of scintillation detectors or not based on coincidence between said pair of scintillation detectors in response to said operational mode; and

a programmable photomultiplier cluster circuit responsive to values over said channel signals, said programmable photomultiplier cluster for utilizing a cluster of a first size for localizing detected events and for utilizing a cluster of a second size for localizing detected events in response to said operational mode.

47. An apparatus as described in claim 46 wherein first integration period is utilized for said PET imaging mode and wherein said second integration period is utilized for said SPECT imaging mode and wherein said first integration period is shorter in length over said second integration period.

48. An apparatus as described in claim 47 wherein said programmable trigger circuit utilizes coincidence between said pair of scintillation detectors for generating said valid event trigger signals when in said PET imaging mode and said programmable trigger circuit does not utilize coincidence between said pair of scintillation detectors for generating said valid event trigger signals when in said SPECT imaging mode.

49. An apparatus as described in claim 48 wherein said first size of said programmable photomultiplier cluster is seven photomultipliers or less and is utilized when in said PET imaging mode and wherein said second size is more than seven photomultipliers and is utilized when in said SPECT imaging mode.